Administrative Core

项目摘要：管理核心 行政核心是最重要的组织单位，是 西奈山的目标是HHEAR实验室中心，直接与HHEAR协调中心(CC)、数据中心合作 中心(DC)和NIH项目工作人员。我们与其他实验室中心就QA/QC进行协作和沟通 包括熟练程度测试、公共QC池、技术副本、保密副本和 将批次效应和实验室间变异性降至最低的方法，我们的团队在 CHEAR的第一个赠款周期。我们进行内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 按照CC的指示(即，如果根据需求需要特定的生物标志物)。我们每周组织一次指导 协调中心内部工作流程的中心委员会(SC)会议，包括接收样品发货， 重新标记、跟踪并进入我们的实验室信息管理系统(LIMS)。我们组织了 PI/客户咨询会议，在会议上我们审查设计的母公司研究，样本 可获得性/质量、研究对象暴露情景、健康表型和所需的化学品类型 要测量的曝光量。然后，我们提出最符合PI/客户目标的建议，而 在进行化验分析之前，解决可能限制可行性的任何科学或技术问题。我们 还跟踪正在进行的作业的进度，并向数据中心的协调中心生成定期报告 和国家卫生研究院的项目。我们与HHEAR数据中心(DC)协调数据报告，确保我们的 数据库的格式正确，并且包含适当的元数据。我们还与DC和 客户/PI对结果的解释(即溶血可能如何影响血浆中的金属水平， 尿液中测得的化学物质是潜在的致肥物等。)以及暴露/表型的统计分析 两性关系。我们组织并实施了一年一度的实验室中心研讨会，让现有的和潜在的 客户接触分析方法学。我们是唯一一个组织这样一次会议的实验室中心 CHEAR以暴露组学为主题，吸引了200名科学参与者。我们使用基于Web的LIMS 通过Lab Hub系统跟踪作业进度并实时评估QA/QC 分析。总而言之，我们1)协调实验室中心内部和外部与 协调中心、数据中心、PI/客户端和NIH计划；2)制定程序、协议和 系统检查以确保样品流向正确的资源/核心，并遵守QA/QC协议 3)维护用户友好的LIMS，便于样品跟踪，防止不匹配 样品和结果，并与数据中心的需求相结合；4)提供科学咨询 为PI/客户提供服务，使他们的研究结果的信息和质量最大化；5)确保反馈 通信发生在客户端和资源/核心之间，并且此信息以透明方式传递 向CC和NIH和6)确保标记的Lab Hub计划的透明财务管理。

Project Summary: Administrative Core The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Targeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing, common QC pools, technical replicates, blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC (i.e. if specific biomarkers are needed based on demand). We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra-Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability/quality, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center, Data Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (i.e. how hemolysis may impact levels of metals in plasma, which chemicals measured in urine are candidate obesogens etc.) and the statistical analysis of exposure/phenotype relationships. We organize and implement an annual Lab Hub workshop that engages existing and potential clients in Exposure assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR which was themed on exposomics and drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Tageted Lab Hub program.