Husbandry and Management Core

摘要 中国人民解放军一直保持着一个SPF印度原产恒河猴的繁育群体， 已经十九年了。这个群体有两种不同水平的SPF恒河猴。水平的人口 1只动物对4种持久性病毒(SIV、SRV、STLV和B病毒)均为阴性。二级动物 7种持久性病毒(SIV、SRV、STLV、SFV、RRV、RhCMV和B病毒)均为阴性。目标是 畜牧管理的核心是扩大SPF级动物的数量，以满足 艾滋病基金调查人员的需求调查宿主微生物群和 艾滋病疫苗和治疗。SPF2动物的比例将在保持的同时增加 总的菌落大小。畜牧业和管理核心将与病毒测试一起工作 核心来评估可能增加的2种病毒(腺相关病毒， 淋巴分泌病毒)用于SPF排除。我们还将与Genetics Management Core进行评估 将Mamu B*17添加到菌落的MHC分型面板中。最后，畜牧业和 管理核心将系统地收集粪便微生物群和外周淋巴细胞 每两年进行一次体检的SPF动物将保存在生物储存库中，供 从事艾滋病毒/艾滋病研究的调查人员。

Abstract The CNPRC has maintained a breeding colony of SPF Indian-origin rhesus macaques SPF for over nineteen years. This colony has two different levels of SPF rhesus. The population of Level 1 animals are negative for 4 persistent viruses, (SIV, SRV, STLV, and B virus). Level 2 animals are negative for 7 persistent viruses (SIV, SRV, STLV, SFV, RRV, RhCMV, and B virus). The goal of the Husbandry and Management Core is to expand the number of SPF Level 2 animals to meet the needs of AIDS funds investigators investigating interaction between the host microbiome and AIDS vaccine and therapies. The percentage of SPF2 animals will be increased while maintaining the overall colony size. The Husbandry and Management Core will work with the Viral Testing Core to evaluate the possible addition of 2 more viruses (Adeno-associated virus, Lymphocryptovirus) for SPF exclusion. We will also evaluate with the Genetics Management Core the addition of Mamu B*17 to the MHC typing panel for the colony. Finally, the Husbandry and Management Core will systematically collect fecal microbiome and peripheral lymphoid cells from SPF animals at their biannual physical exams to be maintained in the biorepository for use by investigators conducting HIV/AIDS research.