Dartmouth Cystic Fibrosis Training Program

在这项申请中，我们建议继续资助达特茅斯囊性纤维化培训计划 （DCFTP）。正在寻求对全面、高度互动的部门间培训的持续支持 计划与CF基础和转化科学的重点。该计划的总体理念 是使用以疾病为中心的方法来教授基础和翻译的基本概念， 科学在动态的背景下，多学科研究和基于团队的指导 环境在本次提交中，我们建议每年直接资助4名学员。我们的计划汇集了 来自各个部门的22名专职教师培训师的才能-我们目前的计划 包括生物化学和细胞生物学，化学，分子系统等系的教师 生物学、医学、微生物学/免疫学、流行病学、儿科学和工程学-提供 为博士和MD/PhD学生提供CF相关研究指导。DCFTP将在以下环境中运行： 研究基地已经有丰富的基础，转化和临床CF相关研究。CF研究 达特茅斯的一个项目已经从1997年的三名研究人员和一项NIH资助发展成为一个社区， 世界一流的科学家，目前每年获得2110万美元的研究经费直接成本（96万美元）， 调查者平均值）。达特茅斯还将提供约3960万美元的机构支持，包括直接支持 DartCF，我们的培训计划和附属的研究生课程，在未来5年。我们的培训 教师使用的方法，包括临床队列研究，定量方法， 实验室和动物研究;因此，我们的学员接触到广泛的科学 回答有影响力的科学问题的策略。DCFTP参与培训学院， 包括博士，医学博士和医学博士/博士研究人员，在一系列学科工作，CF研究为中心 专注;所有培训学院进行研究，资金充足，并教导和指导我们的学员。这 一群基础和医生科学家研究人员积极从事CF相关研究， 细胞生物学、结构生物学、微生物学、免疫学、微生物组学、遗传学、生物信息学 统计学和蛋白质组学。我们计划的一个特点是我们的培训密切和一致的互动 教师与我们的DCFTP学员通过DCFTP赞助的一般和学员特定的活动，包括 每周的研究会议，课程，期刊俱乐部，和我们的年度务虚会。培训补助金和DCFTP- 赞助的、针对受训者的增强型活动提供了一个统一的基础， 这一群体的互动性质（过去5年中38份合作出版物证明了这一点， 我们的22个培训和9个附属学院）和这些学院举行的合作赠款。

In this application, we propose continued funding to the Dartmouth Cystic Fibrosis Training Program (DCFTP). Continuing support is sought for a comprehensive, highly interactive, interdepartmental training program with an emphasis on CF basic and translational science. The overall philosophy of the program is to use a disease-centered approach to teach fundamental concepts of basic and translational science in the context of a dynamic, multidisciplinary research and team-based mentoring environment. In this submission, we propose to directly fund 4 Trainees annually. Our program has pooled the talents of 22 dedicated Faculty Trainers from a wide range of departments—our current program includes faculty in the departments of Biochemistry and Cell Biology, Chemistry, Molecular Systems Biology, Medicine, Microbiology/ Immunology, Epidemiology, Pediatrics, and Engineering—to provide instruction in CF-related research to PhD and MD/PhD students. The DCFTP will function in the context of a Research Base already rich in basic, translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three investigators and one NIH grant in 1997 to a community of world-class scientists that currently secure $21.1M per year in direct costs of research funding ($0.96M per investigator average). Dartmouth will also provide ~$39.6M in institutional support, including direct support to DartCF, our training program and the affiliated graduate programs, over the next 5 years. Our Training Faculty use approaches including the study of clinical cohorts, quantitative methods, and laboratory-based and animal studies; thus, our trainees are exposed to a broad range of scientific strategies to answer impactful scientific questions. The DCFTP participating Training Faculty, which include PhD, MD, and MD/PhD researchers, work in a range of disciplines, with CF research as the central focus; all Training Faculty conduct research, are well funded, and teach and mentor our Trainees. This group of basic and physician-scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural biology, microbiology, immunology, microbiome, genetics, bioinformatics, statistics, and proteomics. A hallmark of our program is the close and consistent interaction of our Training Faculty with our DCFTP Trainees via DCFTP-sponsored general and Trainee-specific activities, including weekly research meetings, courses, journal clubs, and our annual retreat. Training-grant funds and DCFTP- sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the strikingly interactive nature of this group (evidenced by 38 collaborative publications over the past ~5 years among our 22 Training and 9 Affiliated Faculty) and of the collaborative grants held by these faculty.