Force-from-lipids biophysical principle underlying mechanotransduction

该项目的主要目的是通过对压电机械受体通道的结构和功能研究，确定活细胞中机械转导的进化保守物理原理，压电机械受体通道在动物和人类的触觉和疼痛等感官中起着至关重要的作用。这些通道的突变可引起许多遗传疾病，包括遗传性贫血和关节挛缩。由于它们已被证明对机械刺激的反应方式与从细菌到人类的有机体的机械受体通道相同，因此该项目的预期结果是揭示锚定在物理和化学定律中的机械转导的统一原则，这些定律指导了所有生命形式的力依赖设计。

The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown to respond to mechanical stimuli in the same manner as mechanoreceptor channels of organisms from bacteria to humans the intended outcome of this project is to uncover the unifying principles of mechanotransduction anchored in the laws of physics and chemistry that have guided the force-dependent design of all life forms.