SPATIOTEMPORAL ANALYSIS OF MAGNETOCARDIOGRAM

这项拨款申请旨在扩大生物磁性的使用， 测量进入一个相对较新的研究领域- -胎儿的研究 心脏活动 目前，超声是临床上使用的唯一方法 来评估人类胎儿的心脏活动 发展一个完全 一种安全、无创的技术可以提供补充信息， 意义重大潜在的临床应用包括检测 胎儿心脏异常和胎儿窘迫与缺氧或 酸血症 有强有力的理论证明使用磁 检测胎儿评估。 在此明确提出的试点研究 记录这些优势。 拟议研究的主要目的 是为了检验这一假设，即快速消费品可以用来衡量临床 胎儿心脏功能的重要参数， 怀孕年龄 心脏功能异常的胎儿将被纳入 书房 研究数据还将产生详细的新信息 关于胎儿心率变异性和 FMCG。 拟实现的具体目标如下： 1)检测正常胎儿和新生儿的FMCG波形参数， 心功能异常，包括PR间期、QRS时限、PR-RR 相关性和胎心向量。 2)描述和研究胎心率的发展 胎龄变化很大， 3)开发精确测量位置和方向的方法， 子宫内的胎儿，以便研究其对快速消费品的影响， 可以相对于胎儿显示FMCG映射数据。

This grant application proposes to extend the use of biomagnetic measurement into a relatively new research area- - the study of fetal heart activity. Presently, ultrasound is the only method used clinically to assess heart activity of the human fetus. Development of a completely safe, noninvasive technique that provides complementary information could have great significance. Potential clinical applications include detection of fetal heart anomalies and fetal distress associated with hypoxia or acidemia. There is strong theoretical justification for the use of magnetic detection for fetal assessment. Pilot studies presented here clearly document these advantages. The primary purpose of the proposed research is to test the hypothesis that FMCG can be employed to measure clinically important parameters of fetal cardiac function over a wide range of gestation ages. Fetuses with abnormal heart function will be included in the study. The study data will also yield detailed new information regarding fetal heart rate variability and spatiotemporal properties of the FMCG. The specific aims to be achieved are as follows: 1) To measure FMCG waveform parameters in fetuses and neonates with normal and abnormal heart function, including PR interval, QRS duration, PR-RR correlation, and fetal heart vector. 2) To characterize and study the development of fetal heart rate variability over a wide range of gestational age, 3) To develop methods to accurately measure position and orientation of the fetus in utero so that their influence on the FMCG can be studied and FMCG mapping data can be displayed with respect to the fetus.