SENSORS FOR DETECTION OF EXCESSIVE ALCOHOL CONSUMPTION

描述：(改编自申请者的摘要)本项目 涉及基于生物传感器的检测方法的开发 过量饮酒几个重要标志物的测定 消费：丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶 谷草转氨酶(AST)、谷氨酰转氨酶(GGT)和碳水化合物缺乏 转铁蛋白(CDT)。新颖的传感器设计可实现高效运行 由溶解氧和其他杂散电流引起的干扰 常见干扰物质(如抗坏血酸、尿酸盐)的测量结果为 最小化。在第二阶段计划期间，这项传感器技术将 经过优化，以便提供快速测量，只需要很小的 样本量。这些经过优化的传感器将对 与酗酒和酗酒相关领域的研究人员，并可能 辨证论治在日常临床实践中的重要作用 酒精相关器官损害的诊断和后续研究 酒精中毒治疗计划。

DESCRIPTION: (Adapted from the applicant's abstract) This project involves the development of biosensor based detection methods for the determination of several important markers of excessive alcohol consumption: alanine aminotransferase (ALT), aspartate aminotransferase (AST), y-glutamyltransferase (GGT), and carbohydrate deficient transferrin (CDT). Novel sensor design permits efficient operation where interferences due to dissolved oxygen and other spurious current measurements due to common interferents (e.g., ascorbate, urate) are minimized. During the Phase II program, this sensor technology will be optimized in order to provide rapid measurements requiring only small sample volumes. These optimized sensors will be extremely useful to researchers in fields related to alcoholism and alcohol abuse, and could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs.