MAGNETOENCEPHALOGRAM IN EPILEPSY

我们已经将这笔赠款转给了位于 为我们的研究提供大力支持的好心人医院 从而产生更大的病人数量和更高的工作效率。我们会 在授予的时间内完成拨款的主要目标 格兰特。7通道磁力仪、屏蔽室和PPI工作正常 在我们新的更大的实验室中，同时注册了脑磁图、EEG、ECoG和 1 mm分辨率的MRI数据，尖峰信号具有出色的信噪比 和癫痫发作，以及足够的共面脑磁图阵列的空间覆盖 捕获自发性发作和尖峰的相位反转和零点 在同步128通道ECoG期间。我们研究了大量的 在更多的患者中发生事件，并计划研究大量人群。我们有 确定对每个患者进行综合研究可以改善 定位精度和比较以及较大的患者样本量 是检验我们的假说所必需的。我们将在每一步中扩展研究 五步法的一部分。我们建议研究更多的患者 通过对植入偶极子的脑磁图、EEG和ECoG的完整研究，诱发出 反应、自发尖峰、自发性和诱发性癫痫 每一位病人。我们想要研究尖峰的传播模式和 癫痫发作，以便更准确地量化癫痫的面积和潜伏期 对于外科治疗的重要性。我们将继续比较7兆+128 以37个脑电通道+128个脑电通道确定附加值 一个大型阵列脑磁图系统。我们相信7兆和60兆脑电波的结合 通道可以回答类似于更大的阵列MEG的重要问题 系统。我们将在MEG中使用并改进多个固定偶极子解， 个别患者的EEG和带有MR信息的ECoG，EEG 4外壳 具有个体患者电导测量的模型，我们的 有限元模型，指尾带的局部化和 不同的胫后神经皮质和胫后神经的定位 同步脑磁图和脑电图仪检测自发性和诱发性部分性癫痫 脑磁图+脑磁图。我们将对时空结构进行详细的比较 从多源模型中更好地理解被诱发 反应和较少了解的尖峰和癫痫。

We have transferred the grant to the Neurosciences Institute at the Hospital for the Good Samaritan which has heavily supported our research resulting in larger patient volume and higher productivity. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working well in our new larger laboratory with coregistration of MEG, EEG, ECoG, and MRI data with 1mm resolution, excellent signal-to-noise ratios for spikes and seizures, and adequate spatial coverage of the coplanar MEG array to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous 128 channel ECoG. We have studied a large number of events in more patients and plan to study large populations. We have determined that a comprehensive study of each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test our hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and spontaneous and induced seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We will continue to compare 7 MEG + 128 EEG channels to 37 MEG + 128 EEG channels to determine the added value of a large array MEG system. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients, an EEG 4 shell model with measurements of conductivities in individual patients, our finite element model, localizations of digit rostrocaudal bands and the different cortices of posterior tibial nerve , and localizations of spontaneous and induced partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure.