CAROTID ARTERY FOLLOW UP STUDY

描述：(改编自调查人员摘要)这是一个修订版 申请竞标续期。以前的病例对照和 横断面研究表明，颅外病变与 颈动脉内膜中层增厚与冠状动脉 疾病(CAD)。目前提议是完成一项纵向研究 为了确定ECIMT快速进展的印象是否在 冠心病患者与未患冠心病的对照组比较是正确的。 这项研究的第二个目的是量化 男性和女性的总体效应和区段特定效应 因为它受基线风险因素和基线ECIMT的影响。 另一个重要的问题是ECIMT的快速发展 导致管腔直径减小。这个小组最近的研究 都认为ECIMT之间可能存在复杂的关系 以及管腔大小。 这项建议是为了完成对一组男性的纵向研究 并对患有和不患有冠心病的女性进行了总计3年的随访。这个 第一个具体目标是获得ECIMT的3年进展率 之前访问的280名受试者的队列。为此，该方法 在研究的3年内，测量ECIMT的范围将保持不变 将涉及目测测量的使用。第二个具体目标 是利用一种新的边缘检测算法来测量超声波 已经进行的研究以及将要进行的研究 完成特定目标1。此方法允许测量两个 管腔直径和ECIMT。这项测量技术将应用于 到基线研究和最后一次随访研究。第三个目标，尽管 未具体说明，是比较视觉和边缘检测 方法。这将提供对潜在的“漂移”的检查 在研究过程中进行目测测量。课程的主题 目前正在跟踪这项调查。

DESCRIPTION: (Adapted from Investigator's Abstract) This is a revised application for a competing continuation. Previous case-control and cross-sectional studies have shown an association between extracranial carotid artery intimal-medial thickening (ECIMT) and coronary artery disease (CAD). The present proposal is to complete a longitudinal study to determine whether the impression of rapid progression of ECIMT in patients with CAD compared to control subjects without CAD is correct. A second purpose of the study is to quantify the magnitude of the overall effect as well as the segment specific effect in men and women as it is influenced by baseline risk factors and baseline ECIMT. Another question of importance is whether rapid progression of ECIMT leads to reduction of the lumen diameter. Recent studies by this group have suggested that there may be a complex relationship between ECIMT and lumen size. The proposal is for completion of a longitudinal study of a group of men and women with and without CAD for a total of 3 years of follow-up. The first Specific Aim is to obtain 3 year progression rates of ECIMT in the previously accessed cohort of 280 subjects. For this Aim, the method of measuring ECIMT will remain constant for the 3 years of the study and will involve the use of visual measurements. The second Specific Aim is to utilize a new edge detection algorithm to measure the ultrasound studies that have already been performed as well as those that would be completed for Specific Aim 1. This method allows measurement of both lumen diameter and ECIMT. This measurement technique will be applied to baseline studies and the last follow-up study. A third aim, although not specifically stated, is to compare the visual and edge-detection method. This will provide a check on the potential for "drift" in the visual measurements made over the course of the study. The subjects for this investigation are currently being followed.