BIOANALYTICAL SEPARATIONS USING CHIRAL POLYMERS

描述：这里提出的研究旨在研究新的 改进的高效液相色谱技术 和毛细管电泳手性分子的分离。这 研究将集中在三个独立的目标上，涉及不同的 高效液相色谱分离和毛细管电泳法分离。第一个目标涉及 手性胶束聚合物流动相的合成与评价 实现手性拆分的添加剂。第二个目标涉及 使用线性多肽作为固定相的评价 实现了手性拆分。第三个组成部分涉及系统化的 将上述两种方案结合起来实现的评估 改进了手性分离。拟议中的研究对许多人来说都很重要 与健康有关的领域，特别是制药和农业领域 工业。最近的研究表明，许多药物以 外消旋混合物，其中一种对映体可能具有药用价值 另一种有毒。外消旋分离方法的改进 混合物是理解这种影响的关键，也是重点。 这项提议。

DESCRIPTION: The research proposed here is designed to study new technologies for improved High Performance Liquid Chromatographic (HPLC) and Capillary Electrophoresis (CE) separation of chiral molecules. This research will focus on three separate objectives involving various aspects of separations by HPLC and CE. The first objective involves the synthesis and evaluation of chiral micelle polymers as mobile phase additives to achieve chiral separation. The second objective involves an evaluation of the use of linear polypeptides as stationary phases to achieve chiral separation. The third component involves the systematic evaluation of combining the two schemes proposed above to achieve improved chiral separations. The proposed research is important to many health related fields, particularly the pharmaceutical and agricultural industries. Recent studies have demonstrated that many drugs exist as racemic mixtures, where one enantiomer may be medicinally beneficial and the other toxic. Improved methodologies for separation of racemic mixtures is the key to understanding such effects and is also the focus of this proposal.