MOLECULAR SPECTROSCOPY INSTRUMENTATION

分子光谱仪器

• 批准号: 3520424
• 负责人: ISIAH M WARNER
• 金额: $ 30.9万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-16 至 1991-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520424
• 关键词: biomedical equipment purchase; circular dichroism; infrared spectrometry; interferometry; polarimetry; stop flow technique; ultraviolet spectrometry

Funds are requested for the purchase of molecular spectroscopy instrumentation. This instrumentation includes a CD spectropolarimeter, a high resolution uv/visible spectrophotometer, a stopped-flow spectrometer, and a Fourier transform infrared (FTIR) spectrometer. All of these instruments will be housed in the Emory University Chemistry Department in the interest of efficient and comprehensive analysis. The research of eleven NIH programs will be enhanced by use of this instrumentation. There are eight NIH funded investigators in the major users group. The minor users group include three young assistant professors who are pursuing careers in biomedical research. The major and minor users are pursuing such diverse biomedical research as the interaction of drugs with proteins, the mechanism of action of anticancer drugs, co-enzyme B12 dependent enzymic processes, metalloanti-HIV drug development, mechanism of action of enzymes with covalently bound flavins, Tc-99m in renal imaging agents, organic synthesis applied to anticancer drugs, peptide inhibitors of protein kinases, conformational analyses of mitogenic growth factors, specific probes of DNA structure and novel methods of mass spectroscopic protein and peptide sequencing. The proposed instrumentation is essential to these research projects.

申请资金购买分子光谱仪 仪器仪表。 该仪器包括 CD 分光旋光计、 高分辨率紫外/可见分光光度计、停流光谱仪、 和傅里叶变换红外（FTIR）光谱仪。 所有这些 仪器将安置在埃默里大学化学系 高效、全面分析的兴趣。 研究的 NIH 的 11 个项目将通过使用该仪器得到增强。 那里 主要用户组中有 8 名 NIH 资助的研究人员。 未成年人 用户群体包括三名年轻的助理教授，他们正在追求 生物医学研究的职业。 主要用户和次要用户都在追求 药物与蛋白质相互作用等多样化的生物医学研究， 抗癌药物的作用机制，依赖于辅酶B12 酶过程、金属抗 HIV 药物开发、作用机制 与共价结合黄素的酶，肾脏显像剂中的 Tc-99m， 有机合成应用于抗癌药物、肽抑制剂 蛋白激酶、促有丝分裂生长因子的构象分析、 DNA结构特异性探针和质谱新方法 蛋白质和肽测序。 所建议的仪器是必不可少的 到这些研究项目。