GENETIC AND EXPERIENTIAL INFLUENCES ON THE DEVELOPMENT OF PRIMATE VOCAL BEHAVIOR

这个项目目前的重点是荷尔蒙、神经和 非人灵长类动物发声表达的药理学因素。 今年的主要发现包括： 1.催产素结合分布的放射自显影研究 在普通绒猴的大脑中发现了催产素的证据 专一性。与125I-催产素结合的部位显示显著减少 当与血管催产素(一种催产素受体拮抗剂)共同处理时， 但当与加压素受体的配体共同治疗时就不是这样了。进一步 对前脑受体部位进行了定位，最多的是 突出的围绕伏隔核和嗅结节。 在基底核/杏仁外侧核区有一个单独的区域。 2.单纯性成年雄性松鼠猴的激素状况 与女性社会群体的接近程度与 女性发声行为。与患有高血压病的男性相邻居住的女性 循环中的睾丸素水平在3周内显示出10倍于 在引入前男性的过程中发出咕噜声和错误，而女性生活在 与睾酮水平较低的男性相邻的人没有表现出任何变化 在他们的声音行为中。

This project is currently focusing on the hormonal, neural and pharmacological factors underlying vocal expression in nonhuman primates. Major findings this year include: 1. An autoradiographic study of the distribution of oxytocin binding sites in the brains of common marmosets found evidence for oxytocin specificity. Sites binding 125I-oxytocin show significant reduction in binding when co-treated with vasotocin (an oxytocin receptor antagonist), but not when co-treated with a ligand for vasopressin receptors. Further localization of forebrain receptor sites was made, with the most prominent encompassing the nucleus accumbens and olfactory tuberculum. A separate area occurs in the nucleus basalis/lateral amygdala region. 2. Hormonal status of single adult male squirrel monkeys living in proximity to a social group of females is correlated with changes in female vocal behavior. Females living adjacent to a male with high circulating testosterone level for 3 weeks showed a 10-fold increase in purrs and errs over pre-male introduction, whereas females living adjacent to a male with low testosterone level did not exhibit any change in their vocal behavior.