PHOTOREACTIVE SELF ASSEMBLED MONOLAYERS

该项目旨在开发和展示一种简单、成本- 高效、广泛适用的薄膜成本计算技术 生物传感器和医疗器械表面的钝化。预防非 蛋白质和其他生物分子的特异性结合是一个主要的未满足的问题 需要大量的生物材料、光学、电气和 遭受污垢的结构表面(蛋白质和细胞粘连， 微生物增殖、摩擦/阻力和腐蚀) 长期接触生理液体，药物，食物， 和海洋水域。提出了一类新的试剂，用于提供 可固定在表面的自组装单分子膜。之后 从水性涂布液自发形成的单层膜上 疏水表面将通过附着到 表面和聚合，产生亲水性部分 为防止生物分子吸附提供了一片“草地”。这 超薄的钝化膜将被增韧并牢牢地固定在 通过分子间的交联性和偶联性实现表面 浮出水面。这一阶段的工作将综合两个测试模型 这一新型多功能自组装车的亚型 单层分子和在三个或更多生物传感器上使用测试它们和 医疗器械材料。 建议的商业应用： 这项第一阶段的工作预计将产生研究规模的数量 八种新试剂的两种亚型，一种新的，优越的类别 用于疏水表面稳定钝化的涂层剂 材料。众多新型生物传感器和植入式医疗设备 应用程序可能会通过这种制造友好型应用程序实现 涂布工艺。可能会带来额外的商业和健康利益 取代目前含有有毒物质的防污涂料 组件。

This project is designed to develop and demonstrate a facile, cost- effective, and broadly applicable thin-film costing technology for the passivation of biosensor and medical device surfaces. Prevention of non- specific binding of proteins and other biomolecules is a major unmet need for a large variety of biomaterial, optical, electrical and structural surfaces which suffer fouling (protein and cellular adhesion, microbial proliferation, friction/drag, and corrosion) from functioning in chronic contact with physiological fluids, pharmaceuticals, foods, and marine waters. A new class of reagents is proposed, for providing self-assembled monolayers which can be fixed on the surface. After spontaneous formation from aqueous coating fluid, the monolayer film on the hydrophobic surface will be stabilized through attachment to the surface and polymerization, resulting in the hydrophilic moieties providing a "field of grass" to prevent biomolecule adsorption. This ultrathin passivating film will be toughened and held firmly to the surface through crosslinking between the molecules and their coupling to the surface. This Phase I effort will synthesize test models of two sub-types of this new class of multi-functional self-assembling monolayer molecule and use-test them on three or more biosensor and medical device materials. PROPOSED COMMERCIAL APPLICATION: This Phase I effort is expected to generate research-scale quantities of eight new reagents in two sub-types of a new, superior class of coating reagents for the stable passivation of hydrophobic surface materials. Numerous new biosensor and implantable medical device applications will potentially be enabled by this manufacturing-friendly coating process. Additional commercial and health benefits could result from the replacement of current antifouling coatings containing toxic components.