SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS

描述：(改编自应用程序)血管的控制 系统由交感神经系统依赖于组织 交感神经元进入特定功能的通路。节后神经节 交感神经元在这一组织中起着关键作用。 形态、神经化学和电生理特征 这些交感神经元的特征有助于它们特定的 功能通路。尽管已知交感神经元在大脑中 血管通路有明显的神经化学特征，但不是 是否知道支配动脉的神经元之间有区别 还有血管。血管阻力和血管阻力之间的功能分离 电容是心血管调节的重要组成部分。四 提出了具体目标：1.测试本地化的唯一性和 支配椎前神经节神经元的递质表型 肠系膜动脉和静脉。2.测试数据的唯一性 椎前神经节神经元的电生理特征 支配肠系膜动脉和静脉的神经。3.描述来源的特征 椎前神经节内部分感觉神经递质的作用 与靶器官(动脉或静脉)相关的器官。4.比较 支配肠系膜动脉和肠系膜动脉的交感神经释放ATP 静脉。实现这些目标将定义神经机制 分别控制电阻和电容容器。这个 内脏循环接收30%的心输出量，并含有大约 占总出血量的三分之一。在原发性高血压中，血管 电容最初是减小的，然后是 抵抗。这项建议中概述的研究将加强我们的 了解这一现象及相关现象的潜在机制。

DESCRIPTION: (Adapted from the application) The control of the vascular system by the sympathetic nervous system depends on the organization of sympathetic neurons into function-specific pathways. The postganglionic sympathetic neuron plays a critical role in this organization. Characteristic morphological, neurochemical and electrophysiological features of these sympathetic neurons contribute to their specific functional pathways. Although it is known that sympathetic neurons in vascular pathways have distinct neurochemical characteristics, it is not known whether there are distinctions between neurons innervating arteries and veins. The functional separation between vascular resistance and capacitance is an important part of cardiovascular regulation. Four specific aims are proposed: 1. Test the uniqueness of the localization and transmitter phenotype of the neurons in prevertebral ganglia that innervate mesenteric arteries and veins. 2. Test the uniqueness of the electrophysiological characteristics of the neurons in prevertebral ganglia that innervate mesenteric arteries and veins. 3. Characterize the source and effects of selected sensory neurotransmitters in prevertebral ganglia that are related to the target organ (artery or vein). 4. Compare the release of ATP from sympathetic nerves innervating mesenteric arteries and veins. Achieving the objectives will define the nervous mechanisms underlying the separate control of resistance and capacitance vessels. The splanchnic circulation receives 30% of the cardiac output and contains about one-third of the total blood volume. In essential hypertension, vascular capacitance is initially reduced and this is followed by changes in resistance. The studies outlined in this proposal will enhance our understanding of the underlying mechanisms of this and related phenomena.