MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS IN EPILEPSY

研究计划将由三项研究组成，这些研究将补充 彼此之间。这项研究的目标是获得对 脑功能正常和异常的动力学机制 下列措施的应用和相互关系： 脑磁图(MEG)、脑感觉诱发电位和 正电子发射计算机断层扫描(PCT)。脑磁图 在两种局灶性癫痫中，脑磁图(MEG)将与脑电同步进行研究 以及全面性癫痫患者，看看脑磁图是否有更好的定位 脑电对癫痫发作灶和脑磁图的影响 提示在全身性“小规模”癫痫发作中存在潜在的诱因。这个 将对局灶性发作间期棘波的脑磁图和脑电波进行比较。 并与病理、深部电极惊厥发作及PCT相关。 那些患有难治性癫痫的患者正在接受评估 加州大学洛杉矶分校的癫痫手术。长潜伏期的时间成分 对听觉诱发电位(T-Complex)进行前后对比研究 前述癫痫手术组的前颞叶切除术 以确定T-复合波是在 切除体积。T-复合体将在相同的患者中进行研究 以上患者在PCT上有局灶性颞叶低代谢，以确定是否 发作间期低代谢区代表抑制减少的区域 或减弱的兴奋，因为同侧T波反应似乎是 IPSP和对侧T复合波似乎主要是EPSP。 上述本地化有重要的实践方面， 临床癫痫治疗机制的探讨。

The Research Plan will be composed of three studies which will complement each other. The goal of the research is to gain new insights into the dynamic mechanisms of normal and abnormal cerebral function by the application and correlation of the following measures: magnetoencephalography (MEG), cerebral sensory evoked potentials and positron emission computed tomography (PCT). The magnetoencephalogram (MEG) will be studied simultaneously with the EEG in both focal epilepsy and generalized epilepsy patients to see if the MEG is better localizing than the EEG for focus of seizure onset and if the MEG current patterns suggest an underlying generator in generalized "petit mal" seizures. The MEG and EEG of the focal interictal spike will be compared with each other and correlated with pathology, depth electrode seizure onsets and PCT in those patients with medically refractory seizures being evaluated for epilepsy surgery at UCLA. The temporal component of the long-latency auditory evoked potential (T-Complex) will be studied before and after anterior temporal lobectomy in the same epilepsy surgery group as mentioned above to determine if the T-Complex is generated inside or outside the volume of resection. The T-Complex will be studied in the same patients as above who have focal temporal hypometabolism on PCT to determine if the interictal zones of hypometabolism represent areas of decreased inhibition or decresed excitation, since ipsilateral T-Complex response appears to be primarily IPSPs and contralateral T-Complex appears to be primarily EPSPs. There are important practical aspects of the above localization and investigation of mechanisms in clinical epilepsy treatment.