COMPREHENSIVE SICKLE CELL CENTER

我们建议建立一个综合性的镰状细胞疾病中心， 将有以下主要目标：1)改善对患有以下疾病的患者的护理 居住在杜克大学集水区的镰状细胞病 医学中心，2)镰状细胞病的临床研究 关于：a)大脑对葡萄糖的代谢，b)心肺功能，c) 髋关节无菌性坏死，3)髋关节的发展和形成 为患者提供有关镰状细胞综合征的信息教育计划， 杂合子，家庭，医生，护士，其他健康专业人员， 以及整个社区。这些信息教育计划将是 与针对教育指导和疾病的镰状细胞筛查联系在一起 并将交织在当前活动状态的镰刀细胞中 基于项目和社区的Sickle Cell项目。4)基础研究 镰状细胞病的科学问题包括：a)特征 和影响，b)变构效应的研究 血红蛋白功能，3)HbS对离子红细胞膜的影响 运输，d)红细胞膜疏松的研究。为了弥漫 在全州范围内执行相关计划，并从 社区，我们将与国家计划和两个活跃的 以社区为基础的镰刀细胞组织。我们将与其他公司通力合作 参与国家镰刀细胞计划的综合中心。

We propose to establish a Comprehensive Sickle Cell Disease Center which will have as its major objectives: 1) Improved care for patients with sickle cell disease residing in the catchment area of Duke University Medical Center, 2) Clinical Research on the effects of sickle cell disease on: a) metabolism of glucose by the brain, b) cardiopulmonary function, c) aseptic necrosis of the hip, 3) Development and institution of information-education programs about sickle cell syndromes for patients, heterozygotes, families, physicians, nurses, other health professionals, and the community at large. These information-education programs will be linked to sickle cell screening directed at education guidance, and disease detection and will be interwoven in the presently active State Sickle Cell Program and community based Sickle Cell Programs. 4) Study of basic scientific problems in sickle cell disease including: a) characterization and influence of hemoglobin geneotype, b) study of allosteric effectors of hemoglobin function, 3) effects of HbS geleation on ionic red cell membrane transport, d) studies of red cell membrane fludity. In order to diffuse the relevant programs throughout the State and to obtain input from the community, we will work with the State Program and two active community-based Sickle Cell groups. We will cooperate fully with other Comprehensive Centers involved in the National Sickle Cell Program.