14 ERA-CAPS An Effector- and Genomics-Assisted Pipeline for Necrotrophic Pathogen Resistance Breeding in Wheat

EfectaWheat是英国（NIAB， FERA）、德国（LFL）、丹麦（AARHUS）、挪威（NMBU）和澳大利亚（CCDM）六个互补研究所的合作伙伴关系。合作伙伴组成了一个多学科团队，重点研究经济上重要的坏死性病原体：坏死性小麦叶斑病群（LSG）：坏死性小麦芽孢对抗性菌（Pn，引起黑斑病；SNB），小麦芽孢酵母（Zt，引起黑斑病；STB）和小麦白斑菌（Ptr，棕斑病；TS）。小麦中最近可用的资源，包括高分辨率遗传作图群体和高密度基因分型，将与病原体中新兴的工具和方法相结合，如病原体基因组重测序和鉴定病原体产生的介导感染的分子（称为“效应器”）。这些方法将补充项目伙伴在所有伙伴国的病原体诊断、毒力评估和现场病理检测方面的专业知识。这些结合起来，为欧洲LSG宿主-病原体相互作用的遗传解剖提供了一个基于基因组学和效应的管道。合作伙伴在作物研究和翻译之间的独特地位确保了项目成果有效地传播到欧洲农业工业。CCDM已经成功地为澳大利亚的SNB和TS实施了这种方法。这个项目将把这种方法推广到欧洲。所产生的所有资源将提供给研究界和工业界，以促进实际开发。

EfectaWheat is a partnership of six complementary institutes from the UK (NIAB, FERA), Germany (LFL), Denmark (AARHUS), Norway (NMBU) and Australia (CCDM). The partners form a multidisciplinary team focusing on the economically important wheat leaf spot group (LSG) of necrotrophic pathogens: Parastagonospora nodorum (Pn, cause of Septoria nodorum blotch; SNB), Zymoseptoria tritici (Zt, Septoria tritici blotch; STB) and Pyrenophora tritici-repentis (Ptr, tan spot; TS).Recently available resources in wheat, including high-resolution genetic mapping populations and high-density genotyping, will be combined with emerging tools and approaches in the pathogens, such as pathogen genome resequencing, and identification of pathogen-produced molecules that mediate infection (termed, 'effectors). These approaches will complement the project partners' expertise in pathogen diagnostics, virulence assessment and field pathotesting across all partner countries. These combine to deliver a genomics- and effector-based pipeline for the genetic dissection of LSG host-pathogen interactions in Europe. The unique positions of partners at the interface between crop research and translation ensure effective dissemination of project outputs to European agri-industry. This approach has been successfully implemented by CCDM for SNB and TS in Australia. This project will extend the approach to Europe. All resources generated will be made available to the research and industrial communities to facilitate practical exploitation.