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Intra and intermolecular steps underpinning vesicular priming

Intra and intermolecular steps underpinning vesicular priming
支持囊泡启动的分子内和分子间步骤
批准号:
DP170100125
负责人:
Prof Frederic Meunier
金额:
$38.52万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31

项目摘要

项目成果

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中文摘要
翻译
这个项目旨在发现分泌囊泡是如何与质膜融合的,这个过程被称为启动。胞吐作用使分泌囊泡融合,是神经元通讯的基础。尽管努力了解囊泡融合,但这些囊泡如何在到达质膜后成为融合能力尚不清楚。本项目将利用单分子成像技术评估关键启动分子的迁移率变化,揭示其在启动过程中的扩散特征。它打算建立一个分子相互作用的综合模型,使最近停靠的囊泡融合能力。这种理解是解开大脑工作原理的关键
英文摘要
This project aims to discover how secretory vesicles fuse with the plasma membrane, a process called priming. The fusion of secretory vesicles by exocytosis underpins neuronal communication. Despite efforts to understand vesicular fusion, how these vesicles become fusion-competent upon arrival at the plasma membrane is unknown. This project will use single molecule imaging to assess mobility changes of key priming molecules and uncover their diffusional signature during priming. It intends to build a comprehensive model of molecular interactions that make a recently docked vesicle fusion-competent. This understanding is key to unravelling how the brain works
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Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
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  • 项目类别:
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  • 资助金额:
    $33.68万
  • 财政年份:
    2023
  • 负责人:
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Super-resolving neurotransmitter release machinery during priming
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Nanoscale imaging of presynaptic proteins in health and disease
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  • 项目类别:
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  • 资助金额:
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  • 负责人:
    Prof Frederic Meunier
  • 依托单位:
Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
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  • 项目类别:
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  • 财政年份:
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  • 负责人:
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  • 依托单位:
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