TRAJECTORY SPECIFICATION IN TARGETED LIMB MOVEMENT

该提案调查了精准生产背后的机制 肢体运动和指向目标的力的变化。四个小组 计划进行大量实验，并探索从试点数据中得出的假设。 首先，我们将确定留下来的轨迹的特征 当响应指向不同距离的目标时不变。 试点数据表明，这种反应在持续时间和 仅在幅度上受控制。我们现在将探索它的一般性 通过确定策略如何受初始更改的影响来控制策略 条件、负荷、准确性和背景。其次，我们将确定如何 实施了控制政策。试点数据与以下观点一致 控制是通过使用激动剂和推拉机制实现的 对抗者。建议使用拮抗剂来线性化 外围植物的属性。每一项的机械贡献 将会被确定。三是探索中央机制。 负责通过新的 范例。导频数据表明，目标刺激由两个 独立的频道。其中一个似乎触发了符合 预先计算的估计。第二次更新了来自刺激计划的估计 信息。第四，小脑潜在的功能缺陷 将对宫缩困难进行分析，以确定鳞片的异常， 更新和更正。

The proposal investigates the mechanisms underlying the accurate production of limb movements and force changes directed towards a target. Four groups of experiments are planned and explore hypotheses derived from pilot data. First, we will determine the features of trajectories which remain invariant when responses are directed to targets at different distances. Pilot data suggests that such responses are regulated in duration and controlled only in amplitude. We will now explore the generality of this control policy by determining how it is affected by changes in initial conditions, loads, accuracy and context. Second, we will determine how the control policy is implemented. Pilot data is compatible with the view that control is achieved through a push-pull mechanism utilizing agonist and antagonist. The antagonist is proposed to be used to linearize the properties of the peripheral plant. The mechanical contributions of each will be determined. Third, we will explore the central mechanisms responsible for specifying response direction and amplitude through a new paradigm. Pilot data indicates that target stimuli is processed by two independent channels. One appears to trigger a response conforming to a pre-computed estimate. The second updates this estimate from stimulus information. Fourth, the functional deficits underlying cerebellar dysmetria will be analyzed to ascertain the abnormalities in scaling, updating and correction.