LITHIUM-SELECTIVE ELECTRODES WITH POLYMERIC IONOPHORES

本提案的目的是开发一种锂离子选择性 电极，主要用于临床测定 锂在躁狂抑郁症患者治疗中的应用 锂 目前可用的电极对锂的选择性不足 相对于钠。 确定了这些电极的选择性 通过有机分子的金属亲和性， 聚合物膜中的载体。 改进的锂离子载体将使 在聚合物膜中作为离子载体的分子。 改进 锂离子载体将能够自动分析全血， 操作员对血液制品的处理最少。 类似电极 钙、钠和钾已经在临床上使用 分析仪市场 该项目的主要目标是改善 最有前途的锂族的锂选择性 通过将离子载体共价连接到柔性乙烯 氧化物和硅氧烷聚合物。 这种离子载体的共价连接 聚合物主链的聚合物 通过防止形成2：1络合物的锂/钠选择性 离子载体和钠。

The objective of this proposal is to develop a lithium ion-selective electrode, primarily for application to the clinical determination of lithium in patients undergoing therapy for manic depression. The lithium electrodes currently available are not sufficiently selective for lithium relative to sodium. The selectivity of these electrodes is determined by the metal affinities of organic molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable molecules that function as ion carriers in polymer membranes. Improved lithium ionophores would enable automated analysis of whole blood with minimal handling of blood products by the operator. Similar electrodes for calcium, sodium and potassium are already in use in the clinical analyzer market. The major goal of the proposed project is to improve the lithium selectivity of the most promising family of lithium ionophores by covalent attachment of the ionophores to flexible ethylene oxide and siloxane polymers. This covalent attachment of the ionophores to a polymer backbone should help reduce aggregation and improve the lithium/sodium selectivity by preventing the formation of 2:1 complexes of the ionophore and sodium.