IMPROVED METHODS OF RED CELL MEASUREMENT PHASE II

这项研究的长期目标是将新技术应用于 数字图像处理技术应用于红细胞的分析。一直以来 在我们的初步和相关研究中表明，这些 这些技术有可能精确和快速地测量 单个红细胞的血红蛋白含量、大小、形状 中心脸色苍白。此外，细胞的亚群可以严格地 根据这些测量的特征变化来定义。 这些技术可以为临床提供一种新的研究工具。 医学，从而增强、更有效地进行贫血诊断。这个 这些(第一阶段)研究的主要目标是确定最佳 测量波长、波长和相关的消光系数， Epsilon Lambda用于测定干红细胞中的血红蛋白 拍了一部血片。这些是重要的常量，是最终设计所必需的 用于测量技术的商业应用的组件。这些 参数的选择将充分考虑不同的类型 红血球中存在的血红蛋白与 用于血红蛋白溶液的Epsilon Lambda。潜在的商业价值 建议的研究在临床实验室领域的应用。 血液分析、仪器和检测。

The long term objective of this research is to apply new techniques of digital image processing to the analysis of red blood cells. It has been demonstrated, in our preliminary and related research, that these techniques have the potential of precise and rapid measurements of individual red cells with regard to their hemoglobin content, size, shape and central pallor. Further, subpopulations of cells can be rigorously defined according to characteristic variations of these measurements. These techniques could provide a new investigative tool for clinical medicine, resulting in enhanced, more efficient, anemia diagnosis. The primary objectives of these (Phase I) studies are to determine the optimum measurement wavelength, Lambda and associated extinction coefficient, Epsilon Lambda for the measurement of hemoglobin in dried red blood cells on a blood film. These are important constants, necessary as final design components for commercial application of the measurement techniques. These parameters will be selected with due consideration for the different types of hemoglobin present in the red cell and the correspondence between EpsilonLambda for solutions of hemoglobin. The potential commercial application of the proposed research is in the area of clinical laboratory blood analysis, instrumentation and testing.