EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS

药物药代动力学与二氧化碳的理论关系 呼气测试结果已被调查，使用充分搅拌的模型 肝脏新陈代谢。肝提取率、萃取率、萃取率对肝素含量的影响 去甲基化代谢，呼气试验药物吸收率 结果在DEC-10计算机上使用MLAB程序包进行模拟。它 证明了一种适合于检测疾病变化的药物 二氧化碳呼气试验的药物代谢状态应为 至少50%通过去甲基化代谢，应该有肝脏提取物 比例为0.2：0.5，口服形式应为 迅速被吸收。

The theoretical relationship of drug pharmacokinetics and carbon dioxide breath test results has been investigated, using the well-stirred model of liver metabolism. The effects of hepatic extraction ratio, fraction metabolized by demethylation, and absorption rate of drug upon breath test results were simulated, using the MLAB package on the DEC 10 computer. It was demonstrated that a drug suitable for detecting changes in drug-metabolizing status via the carbon dioxide breath test should be at least 50% metabolized by demethylation, should have an hepatic extraction ratio of 0.2 to 0.5, and should be administered orally in a form that is rapidly absorbed.