通过二氧化碳呼气试验评价药物代谢状态-猫眼课题宝

通过二氧化碳呼气试验评价药物代谢状态

批准号：

3822962

负责人：

E A LANE

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3822962

关键词：

acetamides alcoholic beverage consumption alcoholism /alcohol abuse breath tests carbon dioxide drug metabolism gastrointestinal drug absorption human subject liver metabolism mass spectrometry methylation toxin metabolism

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中文摘要

翻译

碳源药物美沙西丁在人体内的总处置已经对二氧化碳呼气测试进行了调查。血浆和尿液浓度美沙西丁及其代谢物对乙酰氨基酚、对乙酰氨基酚葡萄糖和对乙酰氨基酚的测定采用高效液体法。层析法。呼气中的13C-二氧化碳是由同位素比值质谱学。美沙西丁剂量的分数脱甲基化是根据清除概念计算的，也是从单次给药后尿代谢物的测定对乙酰氨基酚。结果发现，100%的美沙星剂量是脱甲基化为对乙酰氨基酚，但只有51%的甲基碳原子是以二氧化碳的形式在呼气中消除。

英文摘要

The total disposition in man of methacetin, a drug used in the carbon dioxide breath test has been investigated. Plasma and urine concentrations of methacetin and its metabolites, acetaminophen, acetaminophen glucoronide and acetaminophen sulfate were measured by high performance liquid chromatography. The 13C-carbon dioxide in expired breath was measured by isotope ratio mass spectrometry. The fraction of the methacetin dose demthylated was calculated according to clearance concepts and also from measurement of urinary metabolites after a single dose each of methacin and acetaminophen. It was found that 100% of the methacin dose was demethylated to acetaminophen, but only 51% of the methyl carbon atoms were eliminated in breath as carbon dioxide.

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