课题基金 / 基金详情

GENETIC MAPPING OF MOUSE CHROMOSOMAL GENES

GENETIC MAPPING OF MOUSE CHROMOSOMAL GENES
小鼠染色体基因的遗传图谱
批准号：
3809609
负责人：
C A KOZAK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809609
关键词：
DNA Retroviridae disease cell transformation chromosomes cytochromes electrophoresis gene expression genetic manipulation genetic mapping hybrid cells laboratory mouse murine leukemia virus nucleic acid hybridization nucleic acid sequence tissue /cell culture tumor antigens virus genetics

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相关文献

中文摘要
翻译
我们最近扩大了我们的努力，染色体定位基因在 实验室老鼠这些研究受到越来越多的关注， 人类基因组计划将小鼠视为一个独特的模型系统。 我们的研究，传统上基于体细胞杂种的分析， 将基因分配到染色体，已经扩展到包括Southern印迹 种间杂交的DNA分析这些研究导致了 编码透明质酸蛋白的基因的染色体定位， 酶、参与药物代谢的基因、脑特异性基因，以及 许多基因参与视觉传导，包括一个cDNA， 视网膜退化是一种遗传性疾病
英文摘要
We have recently expanded our efforts to chromosomally map genes in the laboratory mouse. Such studies have received increased interest through the Human Genome Initiative, which views the mouse as a unique model system. Our studies, traditionally based on the analysis of somatic cell hybrids to assign genes to chromosomes, have been expanded to include Southern blot analysis of DNAs from an interspecies cross. These studies have resulted in the chromosomal mapping of genes encoding zona pellucida proteins and enzymes, genes involved in drug metabolism, brain-specific genes, and numerous genes involved in visual transduction, including a cDNA which may be responsible for retinal degeneration, an inherited disorder.
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GENETIC ASPECTS OF VIRAL ONCOGENESIS IN MICES
GENETIC MAPPING OF MOUSE CHROMOSOMAL GENES
GENETIC ASPECTS OF VIRAL ONCOGENESIS IN WILD MOUSE SPECIES