OSTEOARTHRITIS AND AGING

骨关节炎是老年人最常见的风湿性疾病。 作为巴尔的摩纵向研究中正在进行的OA研究的一部分 老龄化(BLSA)，我们已经评估了代谢和 生理学因素与糖尿病的存在、分布和进展 手部和膝部骨关节炎，男女皆有。在BLSA的234名男性和95名女性中， 在60岁及以上的患者中，65%的患者存在明确的膝盖骨关节炎 相比之下，没有膝盖疼痛的人中这一比例为34%。自尊心的盛行 报告的疼痛与疼痛等级的严重程度显著相关 在130名接受纵向膝关节X光检查的受试者中，我们发现 骨性关节炎的发生或进展发生在0-2级的22例(17%) 基线时骨赘的变化，平均随访3.8q1.1年；以及 基线时的年龄和BMI都显著预测了 发生或进展。在465名40岁及以上的男性和275名女性中， 我们发现，目前吸烟与患糖尿病的风险降低有关。 与年龄和体重指数无关的女性的骨赘形成和膝骨性关节炎。 我们发现，40岁及以上患有当前膝部疼痛的受试者 有氧能力(AC)显著低于没有膝关节疼痛的人 根据膝骨性关节炎的X线变化进行调整，证实了这一假设 在有症状的膝骨性关节炎患者中，AC降低。在340个男人中 208名年龄在40岁及以上的女性，平均脊柱骨密度 (BMD)在膝骨性关节炎患者中，调整后显著增加 年龄和体重指数。髋部骨密度与膝骨性关节炎之间没有关联。 功能。在我们对Hand和Hand的家族聚集性的评估中 在BLSA中推广的OA，我们发现了临床上相关的同胞 调整后远端指间关节骨性关节炎的相关性研究 年龄和性别，但与其他手部部位，膝盖骨关节炎， 或用于多关节骨关节炎(手和膝盖)。

Osteoarthritis (OA) is the most common rheumatic disease of the elderly. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have evaluated the association of metabolic and physiologic factors with the presence distribution, and progression of hand and knee OA in both sexes. In 234 men and 95 women in the BLSA, aged 60 and above, definite knee OA was present in 65% of those with pain compared to 34% of those without knee pain. Prevalence of self- reported pain is significantly associated with the severity of the grade of OA in the knee.In 130 subjects with longitudinal knee xrays, we found that incidence or progression of OA occurred in 22 (17%) with grade 0-2 osteophyte changes at baseline, over a mean follow-up of 3.8q1.1 yrs; and that both age and BMI at baseline significantly predicted time to incidence or progression. In 465 men and 275 women aged 40 and above, we found that current smoking is associated with a decreased risk of osteophyte formation and knee OA in women independent of age and BMI. We found that subjects aged 40 and above with current knee pain have significantly lower aerobic capacity (AC) than those without knee pain adjusted for radiographic changes of knee OA, confirming the hypothesis that AC is diminished in persons with symptomatic knee OA. In 340 men and 208 women aged 40 and above, mean spine bone mineral density (BMD) was significantly greater in those with knee OA, after adjustment for age and BMI. There was no association between hip BMD and knee OA features. In our evaluation of familial aggregation of hand and generalized OA in the BLSA, we found clinically relevant sibling correlations for OA of the distal interphalangeal joints, after adjustment for age and gender, but no association for other hand sItes, for knee OA, or for polyarticular OA (hand and knee).