CONTRIBUTION OF NITRIC OXIDE TO REACTIVE HYPEREMIA

血管(内皮)的内层释放出各种不同的 使平滑肌肉松弛的物质。一个重要的扩张器 被称为一氧化氮。为了研究一氧化氮是否在 反应性充血，我们研究了阻断一氧化氮的作用。 冠状动脉正常和冠状动脉狭窄患者行L-NMMA的临床研究 那些冠状动脉硬化(动脉粥样硬化)的人。 反应性充血可由阻塞肢体的血液供应引起。 暂时允许发生缺血，然后血管扩张 在缺血后的这种情况被称为反应性充血。这项研究 证明扩张过程中释放的一氧化氮有助于 显著地影响血管扩张的幅度，以及对一氧化氮的抑制 氧化物的产生显著降低了血管扩张的程度， 发生在反应性充血期间。这表明血管 压力过程中的膨胀至少部分地依赖于 一氧化氮。

The lining of blood vessels (endothelium) releases a variety of substances that cause the smooth muscle to relax. One important dilator is known as nitric oxide. To study whether nitric oxide is important in reactive hyperemia, we studied the effect of blocking nitric oxide production with L-NMMA in patients with normal coronary arteries and those with hardening of their coronary arteries (atherosclerosis). Reactive hyperemia can be caused by occluding blood supply to a limb temporarily which allows ischemia to occur and then the vasodilatation that follows ischemia is termed reactive hyperemia. The study demonstrated that nitric oxide released during dilation contributes significantly to the magnitude of dilation, and the inhibition of nitric oxide production significantly diminishes the degree of vasodilation that occurs during reactive hyperemia. This suggests that blood vessel dilation during stress is at least partly dependent on the release of nitric oxide.