GLYCOLIPID ANTIGENS EXPRESSED IN CANCER CELLS

糖脂和糖蛋白的糖基化改变经常发生。 在肿瘤组织和培养的癌细胞系中观察到。中的更改 糖基转移酶的表达产生独特的碳水化合物结构 它可以用来区分肿瘤和正常组织以及在某些情况下 病例改变黏附蛋白和受体的生物活性 其中含有改变后的低聚糖。我们正在研究它的特殊性 一些识别低聚糖决定簇的单抗 关于功能重要的分子和硫酸盐的结构 癌细胞产生的与黏附蛋白结合的糖偶联物 如层粘连蛋白和凝血酶原蛋白。目前我们正在研究Globo- 系列硫酸糖脂在人乳腺癌和乳腺癌中的生产 抗人分泌物单抗识别的碳水化合物 识别糖蛋白和糖脂的成分和唾液酸基Lewis a 产生于结肠腺癌。

Altered glycosylation of glycolipids and glycoproteins is frequently observed in tumor tissues and cultured cancer cell lines. Changes in expression of glycosyltransferases produce unique carbohydrate structures which can be used to differentiate tumor from normal tissue and in some cases alter the biological activity of adhesive proteins and receptors which bear the altered oligosaccharides. We are examining the specificity of some monoclonal antibodies that recognize oligosaccharide determinants on functionally important molecules and the structures of sulfated glycoconjugates produced by cancer cells which bind to adhesive proteins such as laminin and thrombospondin. Currently we are examining globo- series sulfated glycolipids produced in human breast cancer and carbohydrates recognized by monoclonal antibodies to human secretory component and sialyl Lewis a which recognize glycoproteins and glycolipids produced in colon adenocarcinomas.