ALPHA-TOCOPHEROL, BETA-CAROTENE LUNG CANCER PREVENTION STUDY

α-生育酚、β-胡萝卜素预防肺癌研究（ATBC 研究）正在研究每日口服α-生育酚（50 mg）的功效 和β-胡萝卜素（20 mg）在一项双盲、随机化2x2析因研究中 在50-69岁男性中预防肺癌的设计试验 吸烟者。该项目是基于实验和流行病学 研究表明这些药物具有潜在的预防作用。 招募工作在1985-1988年期间进行，试验将于1993年结束 平均随访超过6年。邮政调查筛选 潜在的试验参与者被送到芬兰南部的291，000名男性， 76%的人回答。我们邀请了愿意参加的吸烟者（43，000人） 超过29,000人被随机分配到13个研究诊所之一。 每日一粒胶囊方案的依从性仍然很高（97% 辍学率平均每年低于6%。减少 活性药物组的肺癌发病率是主要研究目标; 还将评估其他癌症发生率的差异。 此外，当局亦已完成多项试验研究，以配合这项试验计划 包括可行性研究，验证研究饮食问卷， 以及评估β-胡萝卜素后皮肤变黄和血清水平 局 这项试验是与监测项目合作进行的 癌症预防和控制司和国家公众 芬兰卫生研究所。该项目以前（至1988年） 题为“美国芬兰营养与癌症研究”。"

The Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study (ATBC Study) is investigating the efficacy of daily oral alpha-tocopherol (50 mg) and beta-carotene (20 mg) in a double-blind, randomized 2x2 factorial design trial aimed at preventing lung cancer among 50-69 year old male cigarette smokers. The project is based on experimental and epidemiological research which demonstrates a potential preventive role for these agents. Recruitment took place between 1985-1988, and the trial will end in 1993 after an average follow-up of over 6 years. A postal survey screening for potential trial participants was sent to 291,000 men in southern Finland, and 76% responded. We invited the smokers willing to participate (43,000) to one of 13 study clinics, and over 29,000 were randomized into the study. Compliance to the one capsule daily regimen has remained very high (97% average), and the dropout rate averages less than 6% per year. Reduction of lung cancer incidence in the active agent groups is the primary study goal; differences in the occurrence of other cancers will also be evaluated. Several pilot studies in support of the trial have also been completed including a feasibility study, validation of study dietary questionnaires, and evaluation of skin yellowing and serum levels following beta-carotene administration. This trial is being conducted collaboratively with the Surveillance Program of the Division of Cancer Prevention and Control and the National Public Health Institute of Finland. The project was previously (through 1988) entitled "U.S. Finland Studies of Nutrition and Cancer."