THE EFFECT OF SODIUM FLUORIDE ADMINISTRATION ON RADIATION INDUCED OSTEOSARCOMAS

NTP已经赞助了两项氟化钠致癌性研究。 F344大鼠和B6C3F1小鼠组接受0、25、100和175 ppm 饮用水中的氟化钠（NaF）。 一种可疑的致瘤性 雄性大鼠出现反应，但雌性大鼠无反应 大鼠或小鼠。 雄性大鼠似乎对潜在的 NaF的致癌作用高于雌性大鼠或小鼠。 自辐照以来 可以改变产生不同的骨肉瘤率， 研究将是一个明显的手段，评估可能的促进 NaF的活性。 目的是确定辐射是否 诱导的大鼠骨肉瘤的影响暴露于氟化钠在 饮用水 雄性F344大鼠接受3000拉德的照射， 右后肢有137铯源 10天后，非辐照 照射组大鼠饮用含0和275ppm氟化钠的饮用水 每天，两年。 将对存活大鼠进行评价 组织病理学

The NTP has sponsored two sodium fluoride carcinogenicity studies. Groups of F344 rats and B6C3F1 mice received 0, 25, 100 and 175 ppm sodium fluoride (NaF) in their drinking water. An equivocal tumorigenic response occurred in male rats, but no response was observed in female rats or mice. Male rats appear to be more sensitive to the potential carcinogenic effects of NaF than female rats or mice. Since irradiation can be altered to produce various osteosarcoma rates, this follow-up study would be an obvious means of evaluating the possible promoting activity of NaF. The objective is to determine whether radiation induced osteosarcoma in rats is influenced by exposure to NaF in the drinking water. Male F344 rats received 3000 rads of irradiation to the right rear limb with 137 Cesium source. Ten days later, non-irradiated and irradiated rats were given NaF at 0 and 275 ppm in drinking water daily for 2 years. The surviving rats will be evaluated histopathologically.