EVALUATION OF MICROENCAPSULATION AS A MEANS TO ADMINISTER CHEMICALS IN FEED

微胶囊化是一种用来包裹挥发性物质或化学物质的过程 淀粉微球中的活性化合物使其长期毒性 可以进行喂养研究，以克服潜在的适口性 有问题。在饲料中添加微胶囊柠檬醛的研究与 F344大鼠和B6C3F1雄性大鼠灌胃给药 老鼠。适口性没有受到影响，毒性反应，如身体和 在啮齿动物身上发生了器官重量和组织损伤，无论 暴露途径，表明微胶囊可用于 取代成本最高且不太理想的灌胃给药方式 在长期研究中。在以下情况下可以使用更高剂量的柠檬醛 微胶囊化，最大限度地提高了检测潜力 毒性或致癌反应。进一步的短期毒性研究 比较微胶囊肉桂醛，一种挥发性化学物质，与 在F344大鼠中，通过灌胃给药正在进行中 和B6C3F1小鼠。这些研究将被用来确定靶器官 毒性，并选择长期研究的剂量，通过给 微囊化的化学物质，假定这条首选路线 可以利用管理。

Microencapsulation is a process used to enclose volatile or chemically reactive compounds in starch microspheres so that long-term toxicity feeding studies can be conducted and to overcome potential palatability problems. Studies with microencapsulated citral in feed were compared with chemical administration by gavage in both sexes of F344 rats and B6C3F1 mice. Palatability was unaffected and toxic responses such as body and organ weight and tissue lesions occurred in the rodents, irrespective of route of exposure, indicating that microencapsulation could be used to replace the most costly and less desirable route of gavage administration in long-term studies. Higher doses of citral could be utilized after microencapsulation, resulting in maximization of the detection of potential toxic or carcinogenic responses. Further short-term toxicity studies to compare microencapsulated cinnamaldehyde, a volatile chemical, with chemical administration by gavage, are underway in both sexes of F344 rats and B6C3F1 mice. These studies will be used to determine target organ toxicity, and to select doses for longer-term studies by feeding the microencapsulated chemical, presuming this preferred route of administration can be utilized.