ABUSE LIABILITY OF SMOKELESS TOBACCO PRODUCTS

在两项研究中，烟草使用者用市售的 无烟烟草产品（即，一个人，一个人， 通过吸入空气来吸入汽化的尼古丁的香烟。 使用了滥用责任评估的标准化方法。 无烟烟草研究包括两个阶段。 第一评估的 剂量的影响和咳痰率可能 改变尼古丁的提取和效果。 发现了剂量相关变化 在减少温室气体排放量等措施的作用幅度和持续时间方面， 吸烟欲望和观察到的效果强度。 第二阶段 评价了观察到的效应与血浆中 尼古丁;发现这些与剂量密切相关 给予，从而证实了这种尼古丁系统的可靠性 交付. 这项研究表明，无烟香烟 与商业烟草产品相同的剂量相关效应; 尼古丁水平可以忽略不计，这表明， 尼古丁给药途径可能产生由其 类似于吸烟的外周刺激特性 香烟 测试已完成。

In two studies, tobacco users were tested with a commercially available smokeless tobacco product (i.e., pouches of snuff), and with a smokeless cigarette through which air is sucked to inhale vaporized nicotine. Standardized methods of abuse liability assessment were used. The smokeless tobacco study consisted of two phases. The first evaluated the effects of dose and the possibility that rate of expectoration would alter nicotine extraction and effects. Dose-related changes were found in the magnitude and duration of action of measures such as reduction in urge to smoke and strength of effects observed. The second phase evaluated the relationship of the effects observed to plasma levels of nicotine; these were found to be closely related to the dose administered, thus confirming the reliability of this system of nicotine delivery. The study was smokeless cigarettes indicated similar dose-related effects as those found with the commercial tobacco products; nicotine levels were negligible, suggesting the possibility that this route of nicotine administration may produce effects mediated by its peripheral stimulus properties which resemble those of smoking cigarettes. Testing has been completed.