OPOID SELF-ADMINISTRATION IN HUMANS

戒断状态对药物强化和药物作用的影响 自我给药几乎没有受到药物系统的关注。 虐待研究人员。这是一个严重的遗漏，因为它通常是 假设人类会寻求药物来减轻不适或复发 戒断症状，从而维持身体依赖状态 或在禁欲一段时间后复发。这项研究将检验 以下问题：(A)只有在以下情况下的自治模式 有低剂量的阿片剂，(B)阿片类药物的作用 阿片类药物自我给药的拮抗剂催促戒断，以及(C) 自我给药行为与主观用药的关系 效果。这项研究将对更好地开发更好的 预测药物滥用倾向的方法，因为它结合了两者 滥用责任评估、自我管理和 主观效果测试，在一项研究中。除了寻址 这些重要的药物-行为相互作用，这项研究 可能最终导致更有效的药物滥用治疗方法。 对有阿片类药物滥用史的住宅受试者进行了试点测试 已完成，主要研究应于1991年开始。

The effect of withdrawal states on drug reinforcement and drug self-administration has received little systematic attention from drug abuse researchers. This is a critical omission because it is generally assumed that humans will seek drugs to alleviate unpleasant or relapsing withdrawal symptoms, thus maintaining their state of physical dependence or relapsing after a period of abstinence. This research will examine the following issues: (a) the pattern of self-administration when only low doses of opiates are available, (b) the effect of opioid antagonist-precipitated withdrawal on opiate self-administration, and (c) the relationship between self-administration behavior and subjective drug effects. This research should be useful in the development of better methods to predict abuse liability of drugs, because it combines the two primary strategies of abuse liability assessment, self-administration and subjective effects testing, in a single study. In addition to addressing these important pharmacological-behavioral interactions, this research may ultimately result in more effective treatment methods for drug abuse. Pilot testing of residential subjects with a history of opioid abuse has been completed, and the main study should begin in 1991.