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AIDS RELATED PROTEINS--STRUCTURE AND FUNCTION

AIDS RELATED PROTEINS--STRUCTURE AND FUNCTION
艾滋病相关蛋白质——结构和功能
批准号：
3854956
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3854956
关键词：
CD4 molecule X ray crystallography crystallization electron density enzyme structure human immunodeficiency virus protein structure function ribonuclease III surface antigens virus protein

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中文摘要
翻译
1)已经研究了来自HIV的RNase H的晶体。的 晶体的分辨率约为3.5A。 许多重原子 衍生物已被审查，以提供一个解释 电子密度图 2)由OKT 4A/CD 4复合物获得的晶体已经生长至 X光尺寸。对这些晶体的检查表明， 达到原子分辨率。HIV的结晶条件 正在研究整合酶蛋白。
英文摘要
1) Crystals of the Rnase H from HIV have been investigated. The crystals diffract to about 3.5A resolution. Many heavy atom derivatives have been examined in order to provide an interpretable electron density map. 2) Crystals obtained of the OKT4A/CD4 complex have been grown to X-ray dimensions. Examination of these crystals showed that they do not diffract to atomic resolution. The crystallization conditions for the HIV integrase protein are being investigated.
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