TOXICOLOGY STUDIES OF LEAD

因为目前的硫化铅吸入暴露量标准是3- 比硫化铅大一倍，这些化学品是由NIOSH提名的 以供测试。科学专家研讨会的结论是，最初的 研究应解决不同类型药物的相对生物利用度 铅矿石和纯铅盐的范围确定任何额外的 可能通过吸入途径进行的铅毒性研究。 启动了一项合同研究项目，以比较毒性和 氧化铅、硫化铅、醋酸铅的生物可利用度 来自阿拉斯加的铅精矿。这些化学物质将被喂给老鼠30年 每周监测他们的血铅水平。在研究结束时 将测量血铅、骨铅和尿氨基乙酰丙酸。在……里面 此外，我们会进行内部研究，以评估 血液和血液中不同铅化合物的生化毒性 大脑。

Because the current inhalation exposure standards for lead sulfide are 3- fold greater than for lead sulfide, these chemicals were nominated by NIOSH for testing. A workshop of scientific experts concluded that initial studies should address the comparative bioavailability of different types of lead ores and pure lead salts to determine the scope of any additional studies on lead toxicity that might be conducted by the inhalation route. A contract research project was initiated to compare the toxicity and bioavailability of lead oxide, lead sulfide, lead acetate, and a sample of lead ore concentrate from Alaska. The chemicals will be fed to rats for 30 days and their blood lead levels monitored weekly. At study termination blood and bone lead, and urinary aminolevulinic acid will be measured. In addition, in-house research studies will be conducted to evaluate the biochemical toxicity of the different lead compounds in the blood and brain.