FREQUENCY OF MYOCARDITIS, LEFT VENTRICULAR DYSFUNCTION AND VENTRICULAR

目的：探讨心脏病的临床与组织病理学之间的关系。 获得性免疫缺陷综合征（AIDS）患者的研究结果， 对58例连续尸检的艾滋病患者进行回顾性分析。 26例（45%）有组织病理学心肌炎。其中15个（58%） 有>1例临床心脏异常：6例患有充血性心力衰竭或 左心室（LV）功能障碍，或两者兼而有之，4例室性心动过速 (VT)心电图异常10例， 异常32例无心肌炎。6例（19%） 心包或心电图异常，或两者兼而有之，但没有一个 充血性心力衰竭、LV功能障碍或VT。总体而言，临床心脏 21例患者（36%）发现异常。心肌炎患者 临床心脏异常的发生率显著高于 无心肌炎者58%对19%，P <0.01。所有患者 充血性心力衰竭、左室功能不全或室性心动过速伴心肌炎。因此，在本发明中， 严重的临床心脏异常在艾滋病患者中很常见 与心肌炎有关

To evaluate possible relations between clinical and histopathologic cardiac findings in patients with the acquired immune deficiency syndrome (AIDS), 58 consecutively autopsied AIDS patients were reviewed retrospectively. Twenty-six (45%) had histopathologic myocarditis. Fifteen of these 26 (58%) had >1 clinical cardiac abnormalities: 6 had congestive heart failure or left ventricular (LV) dysfunction, or both, 4 had ventricular tachycardia (VT), 10 had electrocardiographic abnormalities, and 4 had pericardial abnormalities. Of the 32 patients without myocarditis. 6 (19%) had pericardial or electrocardiographic abnormalities, or both, but none had congestive heart failure, LV dysfunction or VT. Overall, clinical cardiac abnormalities were found in 21 patients (36%). Patients with myocarditis had a significantly higher incidence of clinical cardiac abnormalities than patients without myocarditis (58% vs 19%, p <0.01). All patients with congestive heart failure, LV dysfunction or VT had myocarditis. Thus, serious clinical cardiac abnormalities were common in patients with AIDS and were associated with myocarditis.