TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

强迫症(ODD)现在被公认为一种 精神障碍，大约发生在400万人中 只有这个国家。在青少年中，患病率可能是 百分比。 18例成人儿童期发病的正电子发射断层扫描 强迫症表现为前扣带回和右侧最显著的增加 前额叶区域。这种增加与焦虑状态相关。 在扫描过程中，强迫症的严重程度和临床反应 氯丙咪嗪。 51名儿童和青少年参加了正在进行的 氯丙咪嗪与氯丙咪嗪的双盲比较 去甲基米帕明(DMI)。DMI实际上是没有好处的，而 70%的OC受试者至少得到了CMI的一些帮助。 拔毛症(拔毛)似乎也对CMI有反应。 与DMI进行的两次单盲比较和七次双盲比较 已经完成，结果比强迫症更戏剧性。 患有Sydenham舞蹈症的青少年 强迫症的发病率高于仅有风湿热的对照组。这 提示基底节参与强迫症的病理生理过程。

Obsessive Compulsive Disorder (ODD) is now recognized as a common mental disorder, occurring in perhaps four million people in this country alone. In adolescents, the prevalence may be one percent. Positron Emission Tomography with 18 adults with childhood onset OCD shows most significant increase in anterior cingulate and right prefrontal areas. This increase correlates with anxiety state during scan, severity of OCD, and clinical response to clomipramine. Fifty-one children and adolescents are enrolled in an ongoing double-blind comparison of clomipramine (CMI) and desmethylimipramine (DMI). DMI is virtually without benefit, while 70% of OC subjects receive at least some help from CMI. Trichotillomania (hair pulling) also appears to respond to CMI. Two single-blind and seven double-blind comparisons with DMI have been completed and results are more dramatic than for OCD. Adolescents with Sydenham's chorea have significantly higher incidence of OCD than controls with rheumatic fever alone. This implicates the basal ganglia in pathophysiology of OCD.