RESPONSES OF CANINE ARTERIAL WALL TO EXCIMER LASER IRRADIATION

虽然准分子激光器引起精确的微烧蚀， 周围热组织损伤的重要性， 晚期愈合反应必须在安全之前确定， 治疗血管应用。 因此，正常犬 用308nm准分子激光照射股动脉 放射，并在2小时，2天，10天， 和初始治疗后6周。 灌注固定血管 通过光、扫描和透射对标本进行分析 电镜 在激光治疗后两小时， 内皮细胞脱落并被血小板覆盖。 一 光滑单层轴向排列的正常内皮细胞， 10天时无表面机化血栓。 6点 周，没有动脉瘤，也没有重要的表面 增生反应。 因此，有利的急性和慢性 血管组织的病理反应表明， 激光适用于临床血管成形术。

Although excimer lasers cause precise microablation without surrounding thermal tissue injury, the importance of early and late healing responses must be determined prior to safe therapeutic vascular applications. Therefore, normal canine femoral artery segments were exposed to 308nm excimer laser radiation and animals were sacrificed at 2 hours, 2 days, 10 days, and 6 weeks after initial treatment. Perfusion fixed vascular specimens were analyzed by light, scanning, and transmission electron microscopy. At two hours, after laser treatment the endothelium was desquamated and covered by platelets. A smooth monolayer of axially aligned normal endothelial cells was present without surface organizing thrombus by 10 days. At 6 weeks, there were no aneurysms and no important surface hyperplastic responses. Thus, favorable acute and chronic pathologic responses in vascular tissue suggest that the excimer laser is suitable for clinical angioplasty procedures.