GENETIC CONTROL OF RESISTANCE TO FRIEND VIRUS IN WILD MOUSE POPULATIONS

野生小鼠病毒性白血病发生的遗传学研究揭示 这些小鼠与近亲繁殖的品系有很大的不同。分析 各种野鼠种群已经表明，几乎所有的野鼠都缺乏 生态型-MuLV相关序列。具有生态寄主范围的MUV具有 从黑曲霉(M.hortulanus)、卡氏分枝杆菌(M.Castaneus)和磨毛分枝杆菌(M.molossinus)中分离得到。 Southern杂交的数据表明，这些病毒中的大多数 近交系小鼠与生态型近交系小鼠的杂交差异 属性和内部限制图。大多数野鼠的细胞也 与近交系小鼠不同的是，它们对外源感染的敏感性不同。 大多数缺乏FV-1基因座上已知等位基因所定义的限制。 遗传杂交表明，其中2只小鼠，斯普雷特斯和M。 Preetextus携带Fv-2的罕见抗性等位基因。这些老鼠也 与实验室小鼠不同的是，它们对异质性小鼠的敏感性不同。 这一性状由一个名为Sxv的1号染色体基因座控制， 这可能代表了MCF-MuLV受体的野鼠多态 轨迹。

Studies on the genetics of viral leukemogenesis in wild mice have revealed that these mice differ substantially from the inbred strains. Analysis of a variety of feral mouse populations have shown that almost all lack ecotropic-MuLV related sequences. MuLVs with ecotropic host range have been isolated from M. hortulanus, M. m. castaneus and M. m. molossinus. Data from Southern blot hybridizations indicate that most of these viruses differ from ecotropic MuLVs of inbred mice in their hybridization properties and internal restriction maps. Cells of most wild mice also differ from inbred mice in their susceptibility to exogenous infection. Most lack the restriction defined by the known alleles at the Fv-1 locus. Genetic crosses demonstrated that 2 of these mice, M spretus and M. praetextus, carry the rare resistance allele at Fv-2. These mice also differ from laboratory mice in their susceptibility to xenotropic MuLVs. This trait is controlled by a single chromosome 1 locus, designated Sxv, which may represent a wild mouse polymorphism of the MCF-MuLV receptor locus.