DETECTION AND ANALYSIS OF H-2 VARIANT CELL LINES FROM MURINE T CELL LYMPHOMAS

BALB/c起源的S-49 T细胞淋巴瘤的各种细胞系正在研究中。 研究H-2抗原的表达。 正常BALB/c淋巴细胞 表达H-2Kd、H-2Dd和H-2Dd抗原。 我们发现， 目前研究的S-49淋巴瘤细胞系并不表达所有这些细胞 表面H-2抗原。 H-2抗原的表达模式， 这些细胞作为（a）抗体和补体;和（B）细胞毒性的靶 T淋巴细胞（CTL）在T细胞中表现出四种不同的H-2d表达模式， 测试的五条线路。 这一系统对今后的研究具有一定的参考价值 主要组织相容性复合体（MHC）表达的调节 抗原，并提高了相对较高的感染率的可能性 这些抗原在相同来源的肿瘤细胞系之间的调节。 过去一年，该项目没有取得任何进展。

Various lines of the S-49 T cell lymphoma of BALB/c origin are being studies for the expression of H-2 antigens. Normal BALB/c lymphocytes express H-2Kd, H-2Dd, and H-2Dd antigens. We have found that the five lines of the S-49 lymphoma thusfar studied do not express all of these cell surface H-2 antigens. The patterns of expression of H-2 antigens using these cells as targets for: (a) antibody and complement; and (b) cytotoxic T lymphocytes (CTL) exhibit four different patterns of H-2d expression in the five lines tested. This system may be of value for investigating regulation of expression of major histocompatibility complex (MHC) antigens, and raises the possibility of a relatively high rate of modulation of these antigens among tumor cell lines of the same origin. No progress was made in this project during the past year.