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PRODUCTION OF COVALENTLY CROSS-LINKED IMMUNE COMPLEXES

PRODUCTION OF COVALENTLY CROSS-LINKED IMMUNE COMPLEXES
共价交联免疫复合物的产生
批准号：
4689944
负责人：
P H PLOTZ
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689944
关键词：
Kupffer's cell antibody formation antibody specificity biological models complement fixation tests crosslink haptens immune complex immunoglobulins immunopathology immunopharmacology intravenous administration liver cells systemic lupus erythematosus

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中文摘要
翻译
正在进行的研究继续了对免疫复合体生物学的早期观察
英文摘要
Studies underway continue earlier observations on immune complex biology using site-specifically cross-linked model complexes. Two major aspects are under study at the moment. First, the hepatic handling of model complexes in auto-immune mice is being studied in detail using organ perfusion. This approach allows a more detailed and subtle understanding than whole animal studies. Auto-immune mice show an abnormality in handling complexes before they are clinically ill. Second, in studies underway, the influence of drugs which are known to ameliorate auto-immune disease upon immune complex handling in normal and auto-immune mice, is being explored.
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会议论文
GENETIC METABOLIC MYOPATHIES--PHOSPHOFRUCTOKINASE/ACID MALTASE DEFICIENCY
IMMUNOPATHOGEN AUTOIMMUNE INFLAMMATORY MYOPATHIES--POLYMYOSITIS/DERMATOMYOSITIS
THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
VIRUSES IN THE INDUCTION OF AUTOANTIBODIES IN HUMANS AND MICE
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