TREATMENT OF HYPERACTIVE CHILDREN WITH MONOAMINE OXIDASE INHIBITORS

30名患有儿童注意力缺陷障碍（ADD）的儿童 用选择性或非选择性MAO抑制剂处理。 的主要调查结果 迄今为止，选择性MAO-A抑制剂氯吉林和 反苯环丙胺，一种非选择性抑制剂， 多动症和提高注意力。 显著降低 尿MHPG排泄量与行为学指标有一定相关性 对MAOIs和D-安非他明都有改善。 然而，这一下降 停药后MHPG持续数周， 安非他明和 MAOI。 这项研究支持改变儿茶酚胺代谢作为介导 兴奋剂药物的影响。 1-丙炔苯丙胺的对照试验， 选择性MAO-B抑制剂，正在进行中。

Thirty children with childhood Attention Deficit Disorder (ADD) have been treated with a selective or nonselective MAO inhibitor. The major findings to date are that both clorgyline, a selective MAO-A inhibitor, and tranylcypromine, a nonselective inhibitor, were effective in decreasing hyperactivity and improving attention. There was a significant decrease in urinary MHPG excretion which showed some correlation with behavioral improvement both on MAOIs and on d-amphetamine. However, this decrease in MHPG persisted for several weeks after drugs were stopped while there was immediate behavioral rebound off drug for both amphetamine and for the MAOIs. The study supports alteration of catecholamine metabolism as mediating the effects of stimulant medication. A controlled trial of 1-deprenyl, a selective MAO-B inhibitor, is ongoing.