HAMSTER SEPARATION MODEL OF DEPRESSION

一种新的仓鼠抑郁症分离模型正在开发中 大鼠行为状态下中枢神经化学变化的分析 可能类似于人类抑郁症的分离。分离的男性 矮小仓鼠体重增加，探索行为减少， 并减少了社交互动。高压液相色谱 脑单胺和代谢物的分析未能检测到显著的 分离仓鼠与滞留仓鼠的差异 男女配对。阿片受体放射自显影分析失败 检测分离仓鼠和配对仓鼠在以下方面的显著差异 ~3H-纳洛酮结合。

A novel hamster separation model of depression is under development for analysis of central neurochemical changes during a behavior state of separation which may be analogous to human depression. Separated male dwarf hamsters show increased body weight, decreased exploratory behaviors, and reduced social interactions. High pressure liquid chromatography assays of brain monoamines and metabolites failed to detect significant differences in separated hamsters as compared to hamsters remaining in male-female pairs. Autoradiographic assays of opiate receptors failed to detect significant differences between separated and paired hamsters on 3H-naloxone binding.