THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

为了找到更好的治疗肌炎的方法，该组织已经 探索了既有药物的使用又以新的方式使用或 联合疗法或新疗法。这些审判实际上是唯一这样的 治疗这种非常罕见的疾病的试验，因此也 用于吸引患者到临床中心进行其他研究 该小组开展的关于肌炎基本机制和 相关或模拟疾病(在ZO1AR 41074-08和ZO1AR中概述 41099-03年度)。 大剂量甲氨蝶呤静脉滴注的随机交叉试验 亚叶酸钙的抢救和口服甲氨蝶呤与甲氨蝶呤的联合应用 硫唑嘌呤已在过去一年完成，并对 结果正在准备公布。 我们已经开始了嘌呤类似物氟达拉滨的治疗试验。 肌炎的症状。一种定量评价大鼠肌肉炎症的方法 肌炎已经被开发出来，并将在现在和未来使用 治疗试验。计划中的16名患者中有13名已经进入 到目前为止，其中近一半的人已经完成了为期六个月的试验 治疗阶段。 抗甲状腺药物他巴唑的试验将在明年开始。 年。之所以选择这种药物，是因为它可以改变肌肉的能力 作为免疫攻击目标的细胞。在过去的一年里， 药物对肌肉和血细胞影响的评价方法 是与NIDDK和NCI合作开发的。

In an attempt to find better ways to treat myositis, the group has explored the use of both established medications used in new ways or combinations or new therapies. These trials are virtually the only such trials of the treatment of this very uncommon condition and thus also serve to draw patients to the Clinical Center for the other research projects carried out by the group on the basic mechanisms of myositis and related or mimicking diseases (outlined in ZO1 AR 41074-08 and ZO1 AR 41099-03). A randomized, crossover trial of high dose intravenous methotrexate with leucovorin rescue and of a combination of oral methotrexate and azathioprine has been completed in the past year and an analysis of the results is being prepared for publication. We have begun a trial of the purine analogue, fludarabine, in the therapy of myositis. A quantitative method of assessing muscle inflammation in myositis has been developed and will be used in current and future therapeutic trials. Thirteen of the planned sixteen patients have entered the trial so far, of whom almost half have completed the six-month treatment phase. A trial of the anti-thyroid drug, methimazole, will be begun in the next year. This agent was chosen because it may alter the ability of muscle cells to serve as a target for immunologic attack. In this past year, the methods for assessing the effect of the drug on muscle and blood cells have been developed in collaboration with NIDDK & NCI.