Disulfide activated protein kinase G Ialpha as a new therapeutic target in sepsis

败血症，通常被称为血液中毒，当细菌进入血液时就会发生。这是一种非常常见的疾病，当它发生时，存活的机会相当低。脓毒症的主要问题是患者的血压变得非常低，他们的血管变得漏水。总而言之，这会造成很大的伤害，许多身体器官没有足够的血液供应，因此它们会受伤。最近，我们发现了一种新的途径，可以降低健康人的血压并促进血管渗漏，现在我们发现，在导致器官损伤的脓毒症过程中，这一途径被过度刺激。在这些研究中，我们希望开发和测试防止这一途径在脓毒症期间被激活的新药。据预测，这种疗法可以防止器官损伤，并最终提高脓毒症患者的存活率。

Sepsis, often referred to as blood poisoning, occurs when bacteria get into the blood stream. This is a very common disease and when it occurs the chances of survival are rather poor. Major issues in sepsis are that the patients' blood pressure becomes very low and their blood vessels become leaky. Together this causes a lot of harm and many of the bodies organs are not supplied with enough blood and so they become injured. Recently we identified a new pathway that lowers blood pressure and promotes vessel leakiness in healthy people, and have now we have found this is over-stimulated during sepsis resulting in organ damage. In these studies we hope to develop and test new drugs that prevent this pathway being actuated during sepsis. Such therapies are predicted to prevent organ damage and ultimately enhance patient survival during sepsis.