PSYCHOPHYSIOLOGY OF SCHIZOPHRENIA

描述（改编自申请人的摘要）：本申请的总体目标 拟议的研究职业奖（K 02）将为PI提供时间：（1） 从事跨学科，多地点的研究计划， 精神分裂症的心理生理学和（2）获得额外的知识， 技能，以便更好地整合认知科学，临床科学和 神经科学 更具体地说，皮肤电活动和前脉冲 将在四个人中测量惊吓眨眼反射的抑制（PPI） 在三个不同地点进行的一系列研究项目， 源自精神分裂症的易患性压力模型。 第一个项目调查皮肤电活动的变化是否可以 有助于预测精神分裂症的症状加重/复发 患者 第二个项目研究精神分裂症PPI缺陷是否 由于自动化过程、受控过程或 两者 第三个项目测试PPI损害是否表现在两个 被动和注意力主动范式也发生在未受影响的兄弟姐妹中 精神分裂症患者。 第四个项目探讨是否 脑结构异常与皮电和PPI有关 精神分裂症患者和典型个体的异常。 在 除了这四个研究项目外，K 02还将允许PI 接受正式和非正式的技术和原则培训， 临床科学和神经科学。

DESCRIPTION (adapted from applicant's abstract): The overall aims of this proposed Research Career Award (K02) are to provide time for the PI to: (1) engage in an interdisciplinary, multi-site program of research on the psychophysiology of schizophrenia and (2) gain additional knowledge and skills in order to better integrate cognitive science, clinical science and neuroscience. More specifically, electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex will be measured in four sets of research projects at three different sites to test predictions derived from a vulnerability-stress model of schizophrenia. The first project investigates whether changes in electrodermal activity can help in the prediction of symptomatic exacerbation/relapse in schizophrenia patients. The second project examines whether schizophrenia PPI deficits are due to dysfunctions in automatic processes, controlled processes, or both. The third project tests whether PPI impairments demonstrated in both passive and attentionally active paradigms also occur in unaffected siblings of schizophrenia patients. The fourth project explores whether abnormalities in brain structures are related to electrodermal and PPI anomalies in schizophrenia patients and schizotypal individuals. In addition to these four research projects, the K02 will permit the PI to receive formal and informal training in techniques and principles of clinical science and neuroscience.