MULTI-CHANNEL, LOW-COHERENCE IMAGING SYSTEM

描述(改编自申请者摘要)：物理科学公司(PSI) 建议开发一种高效的生物成像新方法并将其商业化 基于共焦扫描激光检眼镜(SLO)的原理 以及与光学相干层析成像(OCT)相关的低相干方法。这个 共焦SLO具有许多有价值的诊断功能，但深度分辨率 眼睛被限制在-300微米。OCT已被证明可以提高深度分辨率 超过一个数量级。然而，这些低相干性技术 通常只使用整个光能的一小部分 在给定共焦采样体积的情况下，相应地减少图像采集 运动伪影的敏感度和比率。证明多渠道 可行性在拟议的第一阶段计划中，PSI将组装并演示 一种同时双通道、横向扫描激光成像装置，使用 分立的现成组件。每个通道将对应于一个 在特定固定深度的低相干度距离门。同时，一个原型 紧凑型集成光学器件的设计和第二阶段制造计划将 可支持多达20个通道同时运行，具有 距离门沿共焦样品体积均匀排列。这个 多通道设备将使用更大比例的可用光 从采样体积返回的能量并提供显著的多路传输 在获取图像数据方面的优势。这一优势可以为更多人量身定做 快速成像，较低的光照要求，消除运动伪影， 或者是这些的某种组合。在第二阶段，我们将开发和测试一款紧凑型 集成光学器件的工程样机，并组装 用于临床演示和商业的多通道成像系统 发展。 建议的商业应用：不可用

DESCRIPTION (Adapted from applicant's abstract): Physical Sciences Inc., (PSI) proposes to develop and commercialize an efficient new approach to bio-imaging based upon the principles of the confocal Scanning Laser Ophthalmoscope (SLO) and low -coherence methods related to Optical Coherence Tomography (OCT). The confocal SLO has many valuable diagnostic capabilities, but depth resolution in the eye is limited to -300 um. OCT has been proven to enhance depth resolution by more than an order of magnitude. However, these low-coherence techniques typically use only a small fraction of the light energy available throughout a given confocal sample volume, with correspondingly reduced image acquisition rates, and susceptibility of motion artifacts. To prove multi-channel feasibility in the proposed Phase I program, PSI will assemble and demonstrate a simultaneous two channel, transverse scanning laser imaging device, using discrete, off-the-shelf components. Each channel will correspond to a single low-coherence range-gate at a particular fixed depth. Concurrently, a prototype design and Phase II fabrication plan for a compact integrated optic device will be developed which will enable up to 20 simultaneous channel operation, with range-gates arrayed uniformly along the confocal sample volume. The multi-channel device will use a much larger fraction of the available light energy returning from the sampled volume and provide a significant multiplex advantage in acquiring image data. This advantage can be tailored for more rapid imaging, lower light level requirements, elimination of motion artifacts, or some combination of these. In Phase II, we will develop and test a compact engineering prototype of the integrated optic device, and assemble the multi-channel imaging system for clinical demonstration and commerical development. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE