STABILIZED IMAGING FOR THE SCANNING LASER OPHTHALMOSCOPE

本二期研究的总体目标是建立和记录新一代视网膜成像系统的设计，该系统将在一期研究中展示的视网膜跟踪（RT）技术应用于先进的扫描激光检眼镜（SLO），并展示该系统的临床价值。RT技术可以实现连续，清晰，稳定的SLO图像采集和图像平均，尽管正常的眼球运动。预计临床试验将提供数据，显示rt稳定SLO成像（或TSLO）在诊断和治疗程序以及研究应用中的价值。这些数据一旦公开传播，预计将提高眼科界对TSLO价值的认识，从而提高其市场潜力。广泛的数据、有效的临床系统和工程文件的结合，将为将技术转移到商业制造商提供坚实的基础。与第一阶段不同的是，第二阶段将建立的RT系统将适合临床使用，在简化其控制的同时，纳入改进以提高其跟踪速度，精度和范围。它将在临床和研究应用中进行测试，从简单的验光检查到先进的诊断程序，如血管造影术和视野检查。获得的数据将在技术会议上发表和介绍。拟议的商业应用：拟议研究的成功结果将导致新的，更强大的诊断系统，用于视网膜疾病和其他视觉障碍的早期检测和诊断。该方法将提高扫描激光成像系统及相关设备的适用性和商业价值。改善血管造影，减少染色和降低风险是可能的。治疗过程也可能受益于精确的稳定。预计在这项研究中开发的技术将被纳入一种或多种商业销售给眼科医生的产品中。

The overall objectives of this Phase II research are to build and document the design of a new generation retinal imaging system incorporating the Retinal Tracking (RT) technology demonstrated in Phase I into an advanced Scanning 1aaser Ophthalmoscope (SLO), and to demonstrate the clinical value of that system. The RT technology enables continuous, well- defined, stable SLO image acquisition and image averaging despite normal eye motions. it is anticipated that the clinical tests will provide data showing the value of RT-stabilized SLO imaging (or TSLO) for diagnostic and therapeutic procedures, as well as for research applications. These data, when publicly disseminated, are expected to increase awareness within the ophthalmologic community of the TSLO's value, thereby enhancing its market potential. The combination of extensive data, a working clinical system, and engineering documentation, will provide a solid foundation for transferring the technology to a commercial manufacturer. Unlike Phase I, the RT system to be built in Phase II will be suitable for clinical use, incorporating improvements to enhance its tracking speed, precision and range while simplifying its control. it will be tested in clinical and research applications ranging from simple ophthalmoscopic exams to advanced diagnostic procedures such as angiography and perimetry. Data acquired will be published and presented at technical conferences. PROPOSED COMMERCIAL APPLICATION: The successful outcome of the proposed research will lead to new, more powerful diagnostic systems for the early detection and diagnosis of retinal disease and other visual disorders. The proposed approach will increase the applicability and commercial value of the scanning laser imaging systems and related devices. Improved angiography will be possible with less dye and lower risk. Therapeutic procedures may also benefit from precise stabilization. It is anticipated that the technology developed during this research will be incorporated into one or more products sold commercially to ophthalmologists.