BISPHOSPHONATE ZOLEDRONATE PREVENTS OSTEOPENIA AFTER OVARIECTOMY IN ADULT RHESUS

目的证明渐进式 卵巢切除恒河猴的骨质减少可以通过 使用强效双膦酸盐唑来膦酸治疗。 结果 卵巢切除术导致腰椎骨丢失约8%， 全身。 这是预防剂量依赖性的方式， 唑来膦酸盐。 这项研究是最全面的评估 雌激素耗竭性骨丢失和双膦酸盐的作用 在非人类灵长类动物中的这种损失。 骨骼抬高 转换被清楚地证明，并抑制剂量依赖性 zoledronate的。 生物力学测试观察到骨强度降低 卵巢切除术后，唑来膦酸预防。 这些 结果表明，该化合物将可能证明有效， 绝经后妇女骨质疏松症的防治。 样本的定量组织形态学评估 这项研究正在进行中。 关键词骨质疏松症，二磷酸盐， 雌激素消耗，骨密度，骨强度 Davidowitz，B.一、Banbartz，S.，博姆， K.，& Binkley，N. 1998年饮用水中铅浓度增加 动物护理设施的水。 AALAS当代动物主题 科学37：51-53。 [J]宾克利，N.，Kimmel，D.，Bruner，J.，Haffa，A.， Davidowitz，B.，Meng，C.，Schaffer，V.，绿色，J. 1998唑来膦酸盐 防止卵巢切除术后绝对骨质减少的发展 在成年恒河猴身上。 J. Bone Miner Res. 13：1775-1782. [日]

OBJECTIVE To demonstrate that the development of progressive osteopenia in ovariectomized rhesus monkeys can be prevented by treatment with the potent bisphosphonate zoledronate. RESULTS Ovariectomy produced rapid bone loss of ~8% at the lumbar spine and total body. This was prevented in a dose-dependent fashion by zoledronate. This study was the most comprehensive assessment of estrogen depletion bone loss and the effect of a bisphosphonate compound on this loss in non-human primates. Elevated skeletal turnover was clearly demonstrated and was suppressed dose dependently by zoledronate. Biomechanical testing observed reduced bone strength following ovariectomy which was prevented by zoledronate. These results suggest that this compound will likely prove efficacious in the prevention and treatment of osteoporosis in postmenopausal women. FUTURE DIRECTIONS Quantitative histomorphometric assessment of samples from this study are pending. KEY WORDS osteoporosis, bisphosphonate, estrogen-depletion, bone density, bone strength FUNDING Novartis pharmaceuticals PUBLICATIONS Davidowitz, B. I., Banovetz, S., Boehm, K., & Binkley, N. 1998 Increased lead concentration in the drinking water of an animal care facility. AALAS Contemporary Topics in Animal Science 37:51-53. [J] Binkley, N., Kimmel, D., Bruner, J., Haffa, A., Davidowitz, B., Meng, C., Schaffer, V., Green, J. 1998 Zoledronate prevents the development of absolute osteopenia following ovariectomy in adult rhesus monkeys. J. Bone Miner Res. 13:1775-1782. [J]