MODEL-FREE SIB-PAIR LINKAGE ANALYSIS COMBINING FULL-SIB AND HALF-SIB PAIRS

当为连锁研究取样全兄妹时，半兄妹通常是可用的。提出了一种理论方法，将全兄妹和半兄妹对的信息合并到一个单一的连锁检验中。该方法基于哈斯曼和埃尔斯顿的方法，对一对兄弟姐妹（全或半兄弟姐妹）的平方性状差进行回归，估计等位基因在血统上相同的比例。提出了一个考虑兄弟姐妹间相关性的修正因子来近似检验统计量的分布；模拟用于证明这种近似在许多情况下都能很好地工作，尽管在某些情况下统计量可能具有膨胀的i型误差。-计算机模拟，G.A.S.P，基因组学，兄弟姐妹连锁分析，半兄弟姐妹

When sampling full-sibs for linkage studies, half-sibs are often available. A theoretical method is proposed to combine the information from full-sib and half-sib pairs into a single test for linkage. The method is based on the Haseman and Elston method of regressing the squared trait-difference for a pair of sibs (either full- or half-sibs) on the estimated proportion of alleles shared identical by descent. A correction factor that consideres the correlation among sibs is proposed to approximate the distribution of the test statistic; simulations are used to demonstrate that the approximation works well in many situations, although there are some situations for which the statistic can have an inflated type-I error. - computer simulation, G.A.S.P., genometrics, sib-pair linkage analysis, half-sibs