Personal dosimeter for OPs using nanostructure surfaces

描述(由申请人提供)： 1996年《食品质量保护法》要求重新评估 长期接触杀虫剂的个人，特别是儿童。 鸭嘴兽科技(TM)代表了一种截然不同的方法 确定即时(实时)和累积暴露在这些环境中 环保人员。该平台技术利用了 生物光子学和纳米技术，允许放大和转导 表面的分子识别事件转化为光学信号(Gupta，et.艾尔， 科学。279.1998年)。这项技术提供了快速、灵敏、简单、 和环境监测的经济性。结果可以解释为“On” 只需对外行人员进行最少的培训。它特别适合 用于监测长期、低水平的环境制剂暴露。鸭嘴兽 Technology(TM)可以作为轻量级、非限制性 经久耐用的个人监视器，适合活跃的婴儿和儿童。在这 第一阶段建议，我们将确定最优的检测策略 使用鸭嘴兽技术制造有机磷。这些研究的结果 将用于建造第二阶段的个人剂量计原型 调查。有机磷的检测将作为一种 展示了这一新平台技术的实用性， 灵敏地检测到与监管和 公共卫生机构。 建议的商业应用： 鸭嘴兽技术是一项革命性的平台技术，具有广阔的应用潜力。为了完全满足FQPA(1996)的要求，环境科学领域需要新技术。鸭嘴兽技术可以作为个人、轻型实时或连续剂量计的基础，以监测环境制剂的暴露情况。

DESCRIPTION (provided by applicant): The 1996 Food Quality Protection act mandates a re-evaluation of the risks of long-term exposure of individuals, especially, children, to pesticides. Platypus Technology (TM) represents a radically different approach to determining instantaneous (real time) and cumulative exposure to these environmental agents. This platform technology exploits new principles of biophotonics and nanotechnology that permit amplifications and transduction of molecular recognition events at surfaces into optical signals (Gupta, et. al., Science. 279. 1998). The technology offers speed, sensitivity, simplicity, and economy for environmental monitoring. Results can be interpreted "on site" with minimal training of lay personnel. It is particularly well suited for monitoring chronic, low-level exposure to environmental agents. Platypus Technology (TM) can serve as the basis for a lightweight, nonrestrictive durable personal monitor suitable for active infants and children. In this Phase I proposal, we will determine the optimal strategies for the detection of organophosphates using Platypus Technology. The results of these studies will be used in the construction of a personal dosimeter prototype in Phase II investigations. The detection of organophosphates will serve as a demonstration of the utility of this new platform technology for the rapid, sensitive detection of environmental agents of interest to regulatory and public health agencies. PROPOSED COMMERCIAL APPLICATION: Platypus Technology is a revolutionary platform technology with broad application potential. To fully meet the requirements of the FQPA, 1996, the field of environmental science needs new technologies. Platypus Technology can be the basis for personal, lightweight real time or continuous dosimeters to monitor exposure to environment agents.