NEUROPSYCHOLOGY

项目1(神经心理学)将研究神经心理学。 两组受试者的表现，以便及早确定 阿尔茨海默病(AD)发展的预测因素。 第一组受试者(队列1)由这些个体组成 在上一个供资周期(n=165)中招募和跟踪。一个 第二个样本(队列2)将在下一次资助期间招募 周期(n=106)。两个队列均由对照组(CDR=0)和受试者组成 伴“可疑”AD(CDR=0.05)。项目1将管理一个 对这些参与者进行神经心理测试，以便识别 预测哪些受试者以后会进步的神经心理测试 达到符合AD标准的程度。来自项目1的数据将 还可以与其他项目和核心的数据相结合，以 确定来自所有主要感兴趣领域的变量(即， 神经心理学、SPECT、FMR、遗传学等)最能预测 AD的发展。

Project 1 (Neuropsychology) will examine neuropsychological performance in two cohorts of subjects, in order to determine early predictive factors for the development of Alzheimer's disease (AD). The first group of subjects (Cohort 1) consists of those individuals recruited and followed during the last funding cycle (n=165). A second sample (Cohort 2) will be recruited during the next funding cycle (n=106). Both cohorts consist of controls (CDR=0) and subjects with "questionable" AD (CDR=0.05). Project 1 will administer a neuropsychological battery to these participants in order to identify neuropsychological tests that predict which subjects will later progress to the point where they meet criteria for AD. Data from Project 1 will also be combined with data from other projects and Cores to determine the variables from all of the major domains of interest (i.e., neuropsychology, SPECT, fMR, genetics, etc) that best predict the development of AD.